SIRT5

GENE INFORMATION

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Gene name

SIRT5

Synonyms

Description

Sirtuin 5 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010]

Chromosome

6

Cytoband

p23

Chromosome location (bp)

13574529 - 13615158

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000124523 (version 78.38)

Entrez gene

23408

UniProt

Q9NXA8 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NXA8

Antibodypedia

SIRT5 antibodies
 

PROTEIN VIEW

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SIRT5-001
 
SIRT5-002
 
SIRT5-003
 
SIRT5-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SIRT5-001 ENSP00000368564
ENST00000379262
Q9NXA8
Show all »
Show » Show » 299 32.7 No 0
SIRT5-002 ENSP00000476228
ENST00000606117
Q9NXA8
Show all »
Show » Show » 310 33.9 No 0
SIRT5-003 ENSP00000352830
ENST00000359782
Q9NXA8
Show all »
Show » Show » 292 32 No 0
SIRT5-201 ENSP00000380509
ENST00000397350
Q9NXA8
Show all »
Show » Show » 202 21.7 No 0