EEF1E1

GENE INFORMATION

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Gene name

EEF1E1 (HGNC Symbol)

Synonyms

AIMP3, P18

Description

Eukaryotic translation elongation factor 1 epsilon 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]

Chromosome

6

Cytoband

p24.3

Chromosome location (bp)

8073360 - 8102578

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000124802 (version 78.38)

Entrez gene

9521

UniProt

O43324 (UniProt - Evidence at protein level)

neXtProt

NX_O43324

Antibodypedia

EEF1E1 antibodies
 

PROTEIN VIEW

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EEF1E1-001
 
EEF1E1-002
 
EEF1E1-003
 
EEF1E1-004
 
EEF1E1-005
 
EEF1E1-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EEF1E1-001 ENSP00000425577
ENST00000488226
D6RCQ0
Show all »
Show » 94 10.4 No 0
EEF1E1-002 ENSP00000369038
ENST00000379715
O43324
Show all »
Show » Show » 174 19.8 No 0
EEF1E1-003 ENSP00000424222
ENST00000507463
D6RBD7
Show all »
Show » 150 16.7 No 1
EEF1E1-004 ENSP00000414363
ENST00000429723
O43324
Show all »
Show » Show » 139 15.5 No 1
EEF1E1-005 ENSP00000427572
ENST00000502429
Show » 136 15.2 No 0
EEF1E1-006 ENSP00000427143
ENST00000515633
H0YAH9
Show all »
Show » 56 5.9 No 0