CNOT1 - Gene info - The Human Protein Atlas

Gene name

CNOT1 (HGNC Symbol)

Synonyms

AD-005, CDC39, KIAA1007, NOT1, NOT1H

Description

CCR4-NOT transcription complex, subunit 1 (HGNC Symbol)

Entrez gene summary

Chromosome

Cytoband

q21

Chromosome location (bp)

58519951 - 58629886

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000125107 (version 78.38)

Entrez gene

23019

UniProt

A5YKK6 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CNOT1-001

ENSP00000320949
ENST00000317147

A5YKK6
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A5YKK6 [Direct mapping]
CCR4-NOT transcription complex subunit 1
B7Z6X2 [Target identity:16%; Query identity:100%]
cDNA FLJ61738, highly similar to Homo sapiens CCR4-NOT transcription complex, subunit 1 (CNOT1), transcript variant 1, mRNA {ECO:0000313|EMBL:BAH13408.1}
B3KS60 [Target identity:13%; Query identity:100%]
cDNA FLJ35566 fis, clone SPLEN2005474, highly similar to Homo sapiens CCR4-NOT transcription complex, subunit 1 (CNOT1), transcript variant 1, mRNA {ECO:0000313|EMBL:BAG52622.1}
H3BT18 [Target identity:2%; Query identity:100%]
CCR4-NOT transcription complex subunit 1 {ECO:0000313|Ensembl:ENSP00000456975}
H3BPF1 [Target identity:1%; Query identity:100%]
CCR4-NOT transcription complex subunit 1 {ECO:0000313|Ensembl:ENSP00000455289}

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   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0004535 [poly(A)-specific ribonuclease activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005778 [peroxisomal membrane]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006417 [regulation of translation]
GO:0010467 [gene expression]
GO:0010606 [positive regulation of cytoplasmic mRNA processing body assembly]
GO:0016020 [membrane]
GO:0016070 [RNA metabolic process]
GO:0016071 [mRNA metabolic process]
GO:0030014 [CCR4-NOT complex]
GO:0030331 [estrogen receptor binding]
GO:0031047 [gene silencing by RNA]
GO:0033147 [negative regulation of intracellular estrogen receptor signaling pathway]
GO:0042974 [retinoic acid receptor binding]
GO:0044822 [poly(A) RNA binding]
GO:0048387 [negative regulation of retinoic acid receptor signaling pathway]
GO:0060213 [positive regulation of nuclear-transcribed mRNA poly(A) tail shortening]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
GO:1900153 [positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:2000036 [regulation of stem cell maintenance]

2376

266.9

CNOT1-002

ENSP00000413113
ENST00000441024

A5YKK6
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A5YKK6 [Direct mapping]
CCR4-NOT transcription complex subunit 1
H3BT18 [Target identity:3%; Query identity:100%]
CCR4-NOT transcription complex subunit 1 {ECO:0000313|Ensembl:ENSP00000456975}
H3BPF1 [Target identity:1%; Query identity:100%]
CCR4-NOT transcription complex subunit 1 {ECO:0000313|Ensembl:ENSP00000455289}

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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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1551

173.8

CNOT1-003

ENSP00000455635
ENST00000569240

A5YKK6
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2371

266.4

CNOT1-007

ENSP00000455289
ENST00000565697

H3BPF1
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H3BPF1 [Target identity:96%; Query identity:100%]
CCR4-NOT transcription complex subunit 1 {ECO:0000313|Ensembl:ENSP00000455289}

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SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

CNOT1-008

ENSP00000457869
ENST00000569020

H3BPF1
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H3BPF1 [Target identity:100%; Query identity:100%]
CCR4-NOT transcription complex subunit 1 {ECO:0000313|Ensembl:ENSP00000455289}

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SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

2.8

CNOT1-010

ENSP00000456975
ENST00000564557

H3BT18
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H3BT18 [Target identity:100%; Query identity:100%]
CCR4-NOT transcription complex subunit 1 {ECO:0000313|Ensembl:ENSP00000456975}
H3BPF1 [Target identity:40%; Query identity:100%]
CCR4-NOT transcription complex subunit 1 {ECO:0000313|Ensembl:ENSP00000455289}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

7.1

CNOT1-016

ENSP00000458057
ENST00000567285

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SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005488 [binding]

241

CNOT1-017

ENSP00000454763
ENST00000567133

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

185

20.6

CNOT1-019

ENSP00000454611
ENST00000568917

H3BMZ2
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H3BMZ2 [Target identity:100%; Query identity:100%]
CCR4-NOT transcription complex subunit 1 {ECO:0000313|Ensembl:ENSP00000454611}

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MEMSAT3 predicted membrane proteins
SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005634 [nucleus]

439

49.8

CNOT1-022

ENSP00000456131
ENST00000562046

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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

193

21.6

CNOT1-023

ENSP00000454377
ENST00000569882

H3BMH0
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H3BMH0 [Target identity:100%; Query identity:100%]
CCR4-NOT transcription complex subunit 1 {ECO:0000313|Ensembl:ENSP00000454377}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

277

29.4

CNOT1-201

ENSP00000245138
ENST00000245138

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MEMSAT3 predicted membrane proteins
SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

316

36.1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.