IL37

GENE INFORMATION

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Gene name

IL37 (HGNC Symbol)

Synonyms

FIL1, FIL1(ZETA), FIL1Z, IL-1F7, IL-1H4, IL-1RP1, IL1F7

Description

Interleukin 37 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q14.1

Chromosome location (bp)

112912971 - 112918882

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000125571 (version 78.38)

Entrez gene

27178

UniProt

Q9NZH6 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NZH6

Antibodypedia

IL37 antibodies
 

PROTEIN VIEW

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IL37-001
 
IL37-002
 
IL37-003
 
IL37-004
 
IL37-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL37-001 ENSP00000263326
ENST00000263326
Q9NZH6
Show all »
Show » Show » 218 24.1 No 0
IL37-002 ENSP00000263327
ENST00000352179
Q9NZH6
Show all »
Show » Show » 197 21.9 No 0
IL37-003 ENSP00000263328
ENST00000349806
Q9NZH6
Show all »
Show » Show » 157 17.5 No 0
IL37-004 ENSP00000309208
ENST00000353225
Q9NZH6
Show all »
Show » Show » 178 19.6 No 0
IL37-005 ENSP00000309883
ENST00000311328
Q9NZH6
Show all »
Show » Show » 192 21.5 No 0