VASP

GENE INFORMATION

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Gene name

VASP

Synonyms

Description

Vasodilator-stimulated phosphoprotein (HGNC Symbol)

Entrez gene summary

Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.32

Chromosome location (bp)

45506579 - 45526983

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000125753 (version 78.38)

Entrez gene

7408

UniProt

P50552 (UniProt - Evidence at protein level)

neXtProt

NX_P50552

Antibodypedia

VASP antibodies
 

PROTEIN VIEW

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VASP-001
 
VASP-004
 
VASP-011
 
VASP-012
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

VASP-001 ENSP00000245932
ENST00000245932
P50552
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Show » Show » 380 39.8 No 0
VASP-004 ENSP00000467773
ENST00000590603
K7EQD0
Show all »
Show » 36 3.6 No 0
VASP-011 ENSP00000467061
ENST00000589627
K7ENR7
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Show » 59 6.6 No 0
VASP-012 ENSP00000464742
ENST00000592139
K7EIG8
Show all »
Show » 46 5 No 0