CENPB

GENE INFORMATION

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Gene name

CENPB

Synonyms

Description

Centromere protein B, 80kDa (HGNC Symbol)

Entrez gene summary

This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

p13

Chromosome location (bp)

3783851 - 3786690

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000125817 (version 78.38)

Entrez gene

1059

UniProt

P07199 (UniProt - Evidence at protein level)

neXtProt

NX_P07199

Antibodypedia

CENPB antibodies
 

PROTEIN VIEW

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CENPB-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CENPB-001 ENSP00000369075
ENST00000379751
P07199
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