MMP24

GENE INFORMATION

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Gene name

MMP24 (HGNC Symbol)

Synonyms

MT5-MMP

Description

Matrix metallopeptidase 24 (membrane-inserted) (HGNC Symbol)

Entrez gene summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

q11.22

Chromosome location (bp)

35226654 - 35277000

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000125966 (version 78.38)

Entrez gene

10893

UniProt

Q9Y5R2 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9Y5R2

Antibodypedia

MMP24 antibodies
 

PROTEIN VIEW

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MMP24-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MMP24-001 ENSP00000246186
ENST00000246186
Q9Y5R2
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Show » Show » 645 73.2 Yes 1