GRPR

GENE INFORMATION

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Gene name

GRPR (HGNC Symbol)

Synonyms

BB2

Description

Gastrin-releasing peptide receptor (HGNC Symbol)

Entrez gene summary

Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]

Chromosome

X

Cytoband

p22.2

Chromosome location (bp)

16123556 - 16153021

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000126010 (version 78.38)

Entrez gene

2925

UniProt

P30550 (UniProt - Evidence at transcript level)

neXtProt

NX_P30550

Antibodypedia

GRPR antibodies
 

PROTEIN VIEW

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GRPR-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GRPR-001 ENSP00000369643
ENST00000380289
P30550
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