CAPNS1

GENE INFORMATION

? »

Gene name

CAPNS1 (HGNC Symbol)

Synonyms

30K, CANP, CANPS, CAPN4, CDPS

Description

Calpain, small subunit 1 (HGNC Symbol)

Entrez gene summary

This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Chromosome

19

Cytoband

q13.12

Chromosome location (bp)

36139575 - 36150353

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000126247 (version 78.38)

Entrez gene

826

UniProt

P04632 (UniProt - Evidence at protein level)

neXtProt

NX_P04632

Antibodypedia

CAPNS1 antibodies
 

PROTEIN VIEW

? »
 
 
 « 
 
CAPNS1-001
 
CAPNS1-002
 
CAPNS1-003
 
CAPNS1-004
 
CAPNS1-005
 
CAPNS1-006
 
CAPNS1-007
 
CAPNS1-008
 
CAPNS1-009
 
CAPNS1-010
 
CAPNS1-012
 
CAPNS1-013
 
 » 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CAPNS1-001 ENSP00000246533
ENST00000246533
P04632
Show all »
Show » Show » 268 28.3 No 0
CAPNS1-002 ENSP00000464849
ENST00000588815
P04632
Show all »
Show » Show » 268 28.3 No 0
CAPNS1-003 ENSP00000468041
ENST00000587718
P04632
Show all »
Show » Show » 322 33.8 No 0
CAPNS1-004 ENSP00000466601
ENST00000589146
K7EMQ1
Show all »
Show » Show » 94 10.3 No 0
CAPNS1-005 ENSP00000468591
ENST00000592483
K7ES78
Show all »
Show » 72 5.8 No 0
CAPNS1-006 ENSP00000466386
ENST00000591041
K7EM73
Show all »
Show » Show » 163 16 No 0
CAPNS1-007 ENSP00000466113
ENST00000588780
K7ELJ7
Show all »
Show » Show » 278 29.4 No 0
CAPNS1-008 ENSP00000465575
ENST00000590874
K7EKD8
Show all »
Show » Show » 238 24.8 No 0
CAPNS1-009 ENSP00000475159
ENST00000592354
U3KPR7
Show all »
Show » Show » 100 11.4 No 0
CAPNS1-010 ENSP00000475804
ENST00000586963
U3KQE2
Show all »
Show » Show » 161 18.4 No 0
CAPNS1-012 ENSP00000464903
ENST00000586851
Show » Show » 196 22 No 0
CAPNS1-013 ENSP00000474280
ENST00000590211
Show » 54 5.6 No 0