IRF3 - Gene info - The Human Protein Atlas

IRF3

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	IRF3
Synonyms
Description	Interferon regulatory factor 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	49659569 - 49665875
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000126456 (version 78.38)
Entrez gene	3661
UniProt	Q14653 (UniProt - Evidence at protein level)
neXtProt	NX_Q14653
Antibodypedia	IRF3 antibodies

PROTEIN VIEW

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IRF3-001		IRF3-002		IRF3-004		IRF3-005		IRF3-006		IRF3-007		IRF3-008		IRF3-009		IRF3-010		IRF3-011		IRF3-012		IRF3-017		IRF3-019		IRF3-020		IRF3-022		IRF3-023		IRF3-024		IRF3-025		IRF3-027		IRF3-028		IRF3-201		IRF3-202

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
IRF3-001	ENSP00000366344 ENST00000377139	Q14653 Show all » « Hide Q14653 [Direct mapping] Interferon regulatory factor 3 M0R205 [Target identity:67%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000472223} M0QYT9 [Target identity:65%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470069} M0QYX3 [Target identity:44%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470140} M0QXC8 [Target identity:27%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000469067} M0R0X9 [Target identity:24%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471517} M0R007 [Target identity:23%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470905} M0R0R8 [Target identity:19%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471402} Q71U93 [Target identity:7%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|EMBL:AAD05262.1}	Show » « Hide Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000975 [regulatory region DNA binding] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0039530 [MDA-5 signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071888 [macrophage apoptotic process]	427	47.2	No
IRF3-002	ENSP00000471896 ENST00000601291	Q14653 Show all » « Hide Q14653 [Direct mapping] Interferon regulatory factor 3 M0R205 [Target identity:63%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000472223} M0QYX3 [Target identity:42%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470140} M0QXC8 [Target identity:26%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000469067} M0R0X9 [Target identity:23%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471517} M0R007 [Target identity:22%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470905} M0R0R8 [Target identity:18%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471402} Q71U93 [Target identity:6%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|EMBL:AAD05262.1}	Show » « Hide Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000975 [regulatory region DNA binding] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0009617 [response to bacterium] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0031663 [lipopolysaccharide-mediated signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0032496 [response to lipopolysaccharide] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0039530 [MDA-5 signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043330 [response to exogenous dsRNA] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045351 [type I interferon biosynthetic process] GO:0045358 [negative regulation of interferon-beta biosynthetic process] GO:0050689 [negative regulation of defense response to virus by host] GO:0050715 [positive regulation of cytokine secretion] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0060340 [positive regulation of type I interferon-mediated signaling pathway] GO:0071359 [cellular response to dsRNA] GO:0071888 [macrophage apoptotic process] GO:0097300 [programmed necrotic cell death]	452	49.1	No
IRF3-004	ENSP00000469113 ENST00000597198	Q14653 Show all » « Hide Q14653 [Direct mapping] Interferon regulatory factor 3 M0R205 [Target identity:67%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000472223} M0QYT9 [Target identity:65%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470069} M0QYX3 [Target identity:44%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470140} M0QXC8 [Target identity:27%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000469067} M0R0X9 [Target identity:24%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471517} M0R007 [Target identity:23%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470905} M0R0R8 [Target identity:19%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471402} Q71U93 [Target identity:7%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|EMBL:AAD05262.1}	Show » « Hide Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000975 [regulatory region DNA binding] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0039530 [MDA-5 signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071888 [macrophage apoptotic process]	427	47.2	No
IRF3-005	ENSP00000471358 ENST00000599223	Q14653 Show all » « Hide Q14653 [Direct mapping] Interferon regulatory factor 3 M0R3C2 [Target identity:88%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000473128} M0QYX3 [Target identity:63%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470140} M0R007 [Target identity:34%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470905} Q71U93 [Target identity:10%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|EMBL:AAD05262.1}	Show » « Hide Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000975 [regulatory region DNA binding] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0039530 [MDA-5 signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071888 [macrophage apoptotic process]	300	33.2	No
IRF3-006	ENSP00000310127 ENST00000309877	Q14653 Show all » « Hide Q14653 [Direct mapping] Interferon regulatory factor 3 M0R205 [Target identity:67%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000472223} M0QYT9 [Target identity:65%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470069} M0QYX3 [Target identity:44%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470140} M0QXC8 [Target identity:27%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000469067} M0R0X9 [Target identity:24%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471517} M0R007 [Target identity:23%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470905} M0R0R8 [Target identity:19%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471402} Q71U93 [Target identity:7%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|EMBL:AAD05262.1}	Show » « Hide Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000975 [regulatory region DNA binding] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0039530 [MDA-5 signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071888 [macrophage apoptotic process]	427	47.2	No
IRF3-007	ENSP00000470431 ENST00000600911	M0QZB7 Show all » « Hide M0QZB7 [Target identity:100%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470431} M0R205 [Target identity:70%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000472223} M0QYX3 [Target identity:46%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470140} M0QXC8 [Target identity:29%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000469067} M0R007 [Target identity:25%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470905} M0R0X9 [Target identity:25%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471517} M0R0R8 [Target identity:20%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471402} Q71U93 [Target identity:7%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|EMBL:AAD05262.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000975 [regulatory region DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated]	408	44.5	No
IRF3-008	ENSP00000470512 ENST00000596765	Q14653 Show all » « Hide Q14653 [Direct mapping] Interferon regulatory factor 3	Show » « Hide Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0039530 [MDA-5 signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071888 [macrophage apoptotic process]	154	16.7	No
IRF3-009	ENSP00000470069 ENST00000599144	M0QYT9 Show all » « Hide M0QYT9 [Target identity:100%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470069} M0QXC8 [Target identity:42%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000469067} M0R0X9 [Target identity:37%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471517} M0R0R8 [Target identity:29%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471402}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated]	281	30.8	No
IRF3-010	ENSP00000472582 ENST00000598808	M0QYT9 Show all » « Hide M0QYT9 [Target identity:100%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470069} M0QXC8 [Target identity:42%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000469067} M0R0X9 [Target identity:37%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471517} M0R0R8 [Target identity:29%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471402}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated]	281	30.8	No
IRF3-011	ENSP00000472601 ENST00000593922	M0QYT9 Show all » « Hide M0QYT9 [Target identity:100%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470069} M0QXC8 [Target identity:42%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000469067} M0R0X9 [Target identity:37%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471517} M0R0R8 [Target identity:29%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471402}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated]	281	30.8	No
IRF3-012	ENSP00000472700 ENST00000600022	Q14653 Show all » « Hide Q14653 [Direct mapping] Interferon regulatory factor 3	Show » « Hide Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0039530 [MDA-5 signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071888 [macrophage apoptotic process]	154	16.7	No
IRF3-017	ENSP00000468911 ENST00000596822	M0QX56 Show all » « Hide M0QX56 [Target identity:100%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000468911}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		135	14	No
IRF3-019	ENSP00000470140 ENST00000601809	M0QYX3 Show all » « Hide M0QYX3 [Target identity:99%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470140} M0R007 [Target identity:53%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470905} Q71U93 [Target identity:15%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|EMBL:AAD05262.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000975 [regulatory region DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005737 [cytoplasm]	191	21.1	No
IRF3-020	ENSP00000470905 ENST00000600453	M0R007 Show all » « Hide M0R007 [Target identity:100%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470905} Q71U93 [Target identity:29%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|EMBL:AAD05262.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000975 [regulatory region DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity]	102	11.8	No
IRF3-022	ENSP00000471517 ENST00000593818	M0R0X9 Show all » « Hide M0R0X9 [Target identity:99%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471517} M0R0R8 [Target identity:79%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471402}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated]	106	11.5	No
IRF3-023	ENSP00000469067 ENST00000595034	M0QXC8 Show all » « Hide M0QXC8 [Target identity:100%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000469067} M0R0X9 [Target identity:88%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471517} M0R0R8 [Target identity:70%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471402}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated]	119	13	No
IRF3-024	ENSP00000471402 ENST00000601373	M0R0R8 Show all » « Hide M0R0R8 [Target identity:100%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471402}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated]	84	9.2	No
IRF3-025	ENSP00000473128 ENST00000596756	M0R3C2 Show all » « Hide M0R3C2 [Target identity:100%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000473128} M0QYX3 [Target identity:71%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470140} M0R007 [Target identity:38%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470905} Q71U93 [Target identity:11%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|EMBL:AAD05262.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000975 [regulatory region DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated]	264	29.2	No
IRF3-027	ENSP00000473176 ENST00000593337	M0R3E9 Show all » « Hide M0R3E9 [Target identity:100%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000473176} M0R007 [Target identity:66%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470905} Q71U93 [Target identity:19%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|EMBL:AAD05262.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000975 [regulatory region DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated]	153	17.4	No
IRF3-028	ENSP00000472223 ENST00000598108	M0R205 Show all » « Hide M0R205 [Target identity:100%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000472223} M0QYX3 [Target identity:66%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470140} M0QXC8 [Target identity:41%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000469067} M0R0X9 [Target identity:36%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471517} M0R007 [Target identity:35%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470905} M0R0R8 [Target identity:29%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471402} Q71U93 [Target identity:10%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|EMBL:AAD05262.1}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000975 [regulatory region DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated]	287	31.8	No
IRF3-201	ENSP00000366339 ENST00000377135	M0QYT9 Show all » « Hide M0QYT9 [Target identity:100%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000470069} M0QXC8 [Target identity:42%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000469067} M0R0X9 [Target identity:37%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471517} M0R0R8 [Target identity:29%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|Ensembl:ENSP00000471402}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0006355 [regulation of transcription, DNA-templated]	281	30.8	No
IRF3-202	ENSP00000400378 ENST00000442265	Q14653 Show all » « Hide Q14653 [Direct mapping] Interferon regulatory factor 3 Q71U93 [Target identity:28%; Query identity:100%] Interferon regulatory factor 3 {ECO:0000313\|EMBL:AAD05262.1}	Show » « Hide Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000975 [regulatory region DNA binding] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0039530 [MDA-5 signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071888 [macrophage apoptotic process]	104	12.3	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.