PTPRB

GENE INFORMATION

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Gene name

PTPRB (HGNC Symbol)

Synonyms

PTPB

Description

Protein tyrosine phosphatase, receptor type, B (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Chromosome

12

Cytoband

q15

Chromosome location (bp)

70515866 - 70637440

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000127329 (version 78.38)

Entrez gene

5787

UniProt

P23467 (UniProt - Evidence at protein level)

neXtProt

NX_P23467

Antibodypedia

PTPRB antibodies
 

PROTEIN VIEW

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PTPRB-001
 
PTPRB-003
 
PTPRB-004
 
PTPRB-006
 
PTPRB-007
 
PTPRB-008
 
PTPRB-009
 
PTPRB-010
 
PTPRB-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTPRB-001 ENSP00000334928
ENST00000334414
Show » Show » 2215 249.1 No 1
PTPRB-003 ENSP00000448058
ENST00000550358
F8VU56
Show all »
Show » Show » 2127 239.6 No 1
PTPRB-004 ENSP00000448349
ENST00000551525
F8VSD5
Show all »
Show » Show » 1583 176.6 No 0
PTPRB-006 ENSP00000446982
ENST00000548122
Q6ZR19
Show all »
Show » Show » 1407 157 No 0
PTPRB-007 ENSP00000261266
ENST00000261266
P23467
Show all »
Show » Show » 1997 224.3 Yes 1
PTPRB-008 ENSP00000438927
ENST00000538708
Show » Show » 1907 214.5 Yes 1
PTPRB-009 ENSP00000447302
ENST00000550857
Show » Show » 1907 214.2 Yes 1
PTPRB-010 ENSP00000446934
ENST00000547715
Show » Show » 103 11.2 Yes 0
PTPRB-201 ENSP00000393028
ENST00000451516
Show » Show » 919 102.5 No 0