SMARCA4 - Gene info - The Human Protein Atlas

SMARCA4

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TISSUE

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SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	SMARCA4 (HGNC Symbol)
Synonyms	BAF190, BRG1, FLJ39786, hSNF2b, SNF2, SNF2-BETA, SNF2L4, SNF2LB, SWI2
Description	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	10961001 - 11065395
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127616 (version 78.38)
Entrez gene	6597
UniProt	P51532 (UniProt - Evidence at protein level)
neXtProt	NX_P51532
Antibodypedia	SMARCA4 antibodies

PROTEIN VIEW

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SMARCA4-001		SMARCA4-002		SMARCA4-003		SMARCA4-004		SMARCA4-005		SMARCA4-007		SMARCA4-015		SMARCA4-018		SMARCA4-201		SMARCA4-202

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
SMARCA4-001	ENSP00000343896 ENST00000344626	P51532 Show all » « Hide P51532 [Direct mapping] Transcription activator BRG1 A7E2E1 [Target identity:100%; Query identity:100%] SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 {ECO:0000313\|EMBL:AAI50299.1}; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4, isoform CRA_a {ECO:0000313\|EMBL:EAW84162.1}; cDNA FLJ77531, highly similar to Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4), mRNA {ECO:0000313\|EMBL:BAF82722.1} B4DSI8 [Target identity:52%; Query identity:100%] cDNA FLJ60344, highly similar to Probable global transcription activator SNF2L4 {ECO:0000313\|EMBL:BAG61650.1}	Show » « Hide SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0002039 [p53 binding] GO:0003407 [neural retina development] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006200 [ATP catabolic process] GO:0006337 [nucleosome disassembly] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007070 [negative regulation of transcription from RNA polymerase II promoter during mitosis] GO:0008094 [DNA-dependent ATPase activity] GO:0016020 [membrane] GO:0016514 [SWI/SNF complex] GO:0016817 [hydrolase activity, acting on acid anhydrides] GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides] GO:0030308 [negative regulation of cell growth] GO:0030957 [Tat protein binding] GO:0031492 [nucleosomal DNA binding] GO:0043044 [ATP-dependent chromatin remodeling] GO:0043234 [protein complex] GO:0043923 [positive regulation by host of viral transcription] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0047485 [protein N-terminus binding] GO:0050681 [androgen receptor binding] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060766 [negative regulation of androgen receptor signaling pathway] GO:0070577 [lysine-acetylated histone binding] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]	1647	184.6	No	0
SMARCA4-002	ENSP00000466963 ENST00000590574	P51532 Show all » « Hide P51532 [Direct mapping] Transcription activator BRG1 B3KNW7 [Target identity:45%; Query identity:100%] cDNA FLJ30606 fis, clone CTONG2000330, highly similar to Probable global transcription activator SNF2L4 {ECO:0000313\|EMBL:BAG51479.1}	Show » « Hide SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0002039 [p53 binding] GO:0003407 [neural retina development] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006200 [ATP catabolic process] GO:0006337 [nucleosome disassembly] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007070 [negative regulation of transcription from RNA polymerase II promoter during mitosis] GO:0008094 [DNA-dependent ATPase activity] GO:0016020 [membrane] GO:0016514 [SWI/SNF complex] GO:0016817 [hydrolase activity, acting on acid anhydrides] GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides] GO:0030308 [negative regulation of cell growth] GO:0030957 [Tat protein binding] GO:0031492 [nucleosomal DNA binding] GO:0043044 [ATP-dependent chromatin remodeling] GO:0043234 [protein complex] GO:0043923 [positive regulation by host of viral transcription] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0047485 [protein N-terminus binding] GO:0050681 [androgen receptor binding] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060766 [negative regulation of androgen receptor signaling pathway] GO:0070577 [lysine-acetylated histone binding] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]	1614	181.3	No	0
SMARCA4-003	ENSP00000392837 ENST00000444061	P51532 Show all » « Hide P51532 [Direct mapping] Transcription activator BRG1	Show » « Hide SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0002039 [p53 binding] GO:0003407 [neural retina development] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006200 [ATP catabolic process] GO:0006337 [nucleosome disassembly] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007070 [negative regulation of transcription from RNA polymerase II promoter during mitosis] GO:0008094 [DNA-dependent ATPase activity] GO:0016020 [membrane] GO:0016514 [SWI/SNF complex] GO:0016817 [hydrolase activity, acting on acid anhydrides] GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides] GO:0030308 [negative regulation of cell growth] GO:0030957 [Tat protein binding] GO:0031492 [nucleosomal DNA binding] GO:0043044 [ATP-dependent chromatin remodeling] GO:0043234 [protein complex] GO:0043923 [positive regulation by host of viral transcription] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0047485 [protein N-terminus binding] GO:0050681 [androgen receptor binding] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060766 [negative regulation of androgen receptor signaling pathway] GO:0070577 [lysine-acetylated histone binding] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]	1613	181.3	No	0
SMARCA4-004	ENSP00000464778 ENST00000589677	P51532 Show all » « Hide P51532 [Direct mapping] Transcription activator BRG1	Show » « Hide SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0002039 [p53 binding] GO:0003407 [neural retina development] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006200 [ATP catabolic process] GO:0006337 [nucleosome disassembly] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007070 [negative regulation of transcription from RNA polymerase II promoter during mitosis] GO:0008094 [DNA-dependent ATPase activity] GO:0016020 [membrane] GO:0016514 [SWI/SNF complex] GO:0016817 [hydrolase activity, acting on acid anhydrides] GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides] GO:0030308 [negative regulation of cell growth] GO:0030957 [Tat protein binding] GO:0031492 [nucleosomal DNA binding] GO:0043044 [ATP-dependent chromatin remodeling] GO:0043234 [protein complex] GO:0043923 [positive regulation by host of viral transcription] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0047485 [protein N-terminus binding] GO:0050681 [androgen receptor binding] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060766 [negative regulation of androgen receptor signaling pathway] GO:0070577 [lysine-acetylated histone binding] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]	1616	181.6	No	0
SMARCA4-005	ENSP00000445036 ENST00000541122	P51532 Show all » « Hide P51532 [Direct mapping] Transcription activator BRG1	Show » « Hide SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0002039 [p53 binding] GO:0003407 [neural retina development] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006200 [ATP catabolic process] GO:0006337 [nucleosome disassembly] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007070 [negative regulation of transcription from RNA polymerase II promoter during mitosis] GO:0008094 [DNA-dependent ATPase activity] GO:0016020 [membrane] GO:0016514 [SWI/SNF complex] GO:0016817 [hydrolase activity, acting on acid anhydrides] GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides] GO:0030308 [negative regulation of cell growth] GO:0030957 [Tat protein binding] GO:0031492 [nucleosomal DNA binding] GO:0043044 [ATP-dependent chromatin remodeling] GO:0043234 [protein complex] GO:0043923 [positive regulation by host of viral transcription] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0047485 [protein N-terminus binding] GO:0050681 [androgen receptor binding] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060766 [negative regulation of androgen receptor signaling pathway] GO:0070577 [lysine-acetylated histone binding] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]	1617	181.7	No	0
SMARCA4-007	ENSP00000395654 ENST00000429416	P51532 Show all » « Hide P51532 [Direct mapping] Transcription activator BRG1 A7E2E1 [Target identity:100%; Query identity:100%] SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 {ECO:0000313\|EMBL:AAI50299.1}; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4, isoform CRA_a {ECO:0000313\|EMBL:EAW84162.1}; cDNA FLJ77531, highly similar to Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4), mRNA {ECO:0000313\|EMBL:BAF82722.1} B4DSI8 [Target identity:52%; Query identity:100%] cDNA FLJ60344, highly similar to Probable global transcription activator SNF2L4 {ECO:0000313\|EMBL:BAG61650.1}	Show » « Hide SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000792 [heterochromatin] GO:0000902 [cell morphogenesis] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0001570 [vasculogenesis] GO:0001701 [in utero embryonic development] GO:0001832 [blastocyst growth] GO:0001835 [blastocyst hatching] GO:0001889 [liver development] GO:0002039 [p53 binding] GO:0003407 [neural retina development] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005719 [nuclear euchromatin] GO:0005726 [perichromatin fibrils] GO:0005730 [nucleolus] GO:0006200 [ATP catabolic process] GO:0006337 [nucleosome disassembly] GO:0006338 [chromatin remodeling] GO:0006346 [methylation-dependent chromatin silencing] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007070 [negative regulation of transcription from RNA polymerase II promoter during mitosis] GO:0007399 [nervous system development] GO:0007403 [glial cell fate determination] GO:0007507 [heart development] GO:0008094 [DNA-dependent ATPase activity] GO:0008134 [transcription factor binding] GO:0010424 [DNA methylation on cytosine within a CG sequence] GO:0016020 [membrane] GO:0016514 [SWI/SNF complex] GO:0016817 [hydrolase activity, acting on acid anhydrides] GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides] GO:0019827 [stem cell maintenance] GO:0022008 [neurogenesis] GO:0030198 [extracellular matrix organization] GO:0030216 [keratinocyte differentiation] GO:0030308 [negative regulation of cell growth] GO:0030900 [forebrain development] GO:0030902 [hindbrain development] GO:0030957 [Tat protein binding] GO:0031492 [nucleosomal DNA binding] GO:0035116 [embryonic hindlimb morphogenesis] GO:0035887 [aortic smooth muscle cell differentiation] GO:0043044 [ATP-dependent chromatin remodeling] GO:0043234 [protein complex] GO:0043388 [positive regulation of DNA binding] GO:0043923 [positive regulation by host of viral transcription] GO:0043966 [histone H3 acetylation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0047485 [protein N-terminus binding] GO:0048562 [embryonic organ morphogenesis] GO:0048730 [epidermis morphogenesis] GO:0050681 [androgen receptor binding] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060318 [definitive erythrocyte differentiation] GO:0060347 [heart trabecula formation] GO:0060766 [negative regulation of androgen receptor signaling pathway] GO:0070307 [lens fiber cell development] GO:0070577 [lysine-acetylated histone binding] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]	1647	184.6	No	0
SMARCA4-015	ENSP00000467796 ENST00000586985		Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	113	12.6	No	0
SMARCA4-018	ENSP00000467200 ENST00000592158	K7EP28 Show all » « Hide K7EP28 [Target identity:100%; Query identity:100%] Transcription activator BRG1 {ECO:0000313\|Ensembl:ENSP00000467200}	Show » « Hide Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0042393 [histone binding]	136	15.7	No	0
SMARCA4-201	ENSP00000414727 ENST00000413806		Show » « Hide SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0016817 [hydrolase activity, acting on acid anhydrides] GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]	1681	188.9	No	0
SMARCA4-202	ENSP00000397783 ENST00000450717	Q9HBD4 Show all » « Hide Q9HBD4 [Target identity:100%; Query identity:100%] SMARCA4 isoform 2 {ECO:0000313\|EMBL:AAG24790.1}; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4, isoform CRA_c {ECO:0000313\|EMBL:EAW84164.1}	Show » « Hide SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0016817 [hydrolase activity, acting on acid anhydrides] GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]	1679	188.1	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.