PAICS

GENE INFORMATION

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Gene name

PAICS (HGNC Symbol)

Synonyms

ADE2H1, AIRC, PAIS

Description

Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (HGNC Symbol)

Entrez gene summary

This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q12

Chromosome location (bp)

56435741 - 56461368

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000128050 (version 78.38)

Entrez gene

10606

UniProt

P22234 (UniProt - Evidence at protein level)

neXtProt

NX_P22234

Antibodypedia

PAICS antibodies
 

PROTEIN VIEW

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PAICS-001
 
PAICS-002
 
PAICS-003
 
PAICS-006
 
PAICS-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PAICS-001 ENSP00000424053
ENST00000505164
E9PBS1
Show all »
Show » Show » 413 45.7 No 0
PAICS-002 ENSP00000424907
ENST00000514888
D6RF62
Show all »
Show » Show » 333 37.1 No 0
PAICS-003 ENSP00000382595
ENST00000399688
P22234
Show all »
Show » Show » 432 48 No 0
PAICS-006 ENSP00000421096
ENST00000512576
P22234
Show all »
Show » Show » 425 47.1 No 0
PAICS-201 ENSP00000264221
ENST00000264221
P22234
Show all »
Show » Show » 425 47.1 No 0