LIF

GENE INFORMATION

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Gene name

LIF (HGNC Symbol)

Synonyms

CDF, DIA, HILDA

Description

Leukemia inhibitory factor (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Chromosome

22

Cytoband

q12.2

Chromosome location (bp)

30240447 - 30246851

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000128342 (version 78.38)

Entrez gene

3976

UniProt

P15018 (UniProt - Evidence at protein level)

neXtProt

NX_P15018

Antibodypedia

LIF antibodies
 

PROTEIN VIEW

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LIF-001
 
LIF-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LIF-001 ENSP00000249075
ENST00000249075
P15018
Show all »
Show » Show » 202 22 Yes 0
LIF-002 ENSP00000384450
ENST00000403987
P15018
Show all »
Show » Show » 88 9.6 No 0