POT1

GENE INFORMATION

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Gene name

POT1 (HGNC Symbol)

Synonyms

DKFZp586D211, hPot1

Description

Protection of telomeres 1 (HGNC Symbol)

Entrez gene summary

This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

q31.33

Chromosome location (bp)

124822386 - 124929983

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000128513 (version 78.38)

Entrez gene

25913

UniProt

Q9NUX5 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NUX5

Antibodypedia

POT1 antibodies
 

PROTEIN VIEW

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POT1-001
 
POT1-003
 
POT1-008
 
POT1-010
 
POT1-013
 
POT1-014
 
POT1-016
 
POT1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

POT1-001 ENSP00000350249
ENST00000357628
Q9NUX5
Show all »
Show » Show » 634 71.4 No 0
POT1-003 ENSP00000388921
ENST00000446993
C9JPG9
Show all »
Show » Show » 82 9.2 No 0
POT1-008 ENSP00000416820
ENST00000436534
Show » 138 15.4 No 0
POT1-010 ENSP00000476290
ENST00000487564
V9GY10
Show all »
Show » Show » 77 9 No 0
POT1-013 ENSP00000477258
ENST00000609702
V9GZ00
Show all »
Show » Show » 73 8.1 No 0
POT1-014 ENSP00000476673
ENST00000610141
Show » 119 13.3 No 0
POT1-016 ENSP00000477320
ENST00000608200
V9GZ21
Show all »
Show » Show » 86 9.7 No 0
POT1-201 ENSP00000377002
ENST00000393329
A8MTK3
Show all »
Show » Show » 503 56.8 No 0