PDE11A

GENE INFORMATION

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Gene name

PDE11A

Synonyms

Description

Phosphodiesterase 11A (HGNC Symbol)

Entrez gene summary

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q31.2

Chromosome location (bp)

177623252 - 178108339

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000128655 (version 78.38)

Entrez gene

50940

UniProt

Q9HCR9 (UniProt - Evidence at protein level)

neXtProt

NX_Q9HCR9

Antibodypedia

PDE11A antibodies
 

PROTEIN VIEW

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PDE11A-001
 
PDE11A-002
 
PDE11A-003
 
PDE11A-004
 
PDE11A-006
 
PDE11A-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PDE11A-001 ENSP00000286063
ENST00000286063
Q9HCR9
Show all »
Show » Show » 933 104.8 No 0
PDE11A-002 ENSP00000351232
ENST00000358450
Q9HCR9
Show all »
Show » Show » 683 78 No 0
PDE11A-003 ENSP00000374333
ENST00000389683
Q9HCR9
Show all »
Show » Show » 489 55.7 No 0
PDE11A-004 ENSP00000386539
ENST00000409504
Q9HCR9
Show all »
Show » Show » 575 65.7 Yes 0
PDE11A-006 ENSP00000416884
ENST00000433879
Show » Show » 437 49.7 No 0
PDE11A-007 ENSP00000406922
ENST00000436700
Q53S13
Show all »
Show » Show » 136 15.5 No 0