EIF2AK4

GENE INFORMATION

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Gene name

EIF2AK4 (HGNC Symbol)

Synonyms

GCN2, KIAA1338

Description

Eukaryotic translation initiation factor 2 alpha kinase 4 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]

Chromosome

15

Cytoband

q15.1

Chromosome location (bp)

39934146 - 40035591

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000128829 (version 78.38)

Entrez gene

440275

UniProt

Q9P2K8 (UniProt - Evidence at protein level)

neXtProt

NX_Q9P2K8

Antibodypedia

EIF2AK4 antibodies
 

PROTEIN VIEW

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EIF2AK4-001
 
EIF2AK4-002
 
EIF2AK4-003
 
EIF2AK4-009
 
EIF2AK4-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EIF2AK4-001 ENSP00000263791
ENST00000263791
Q9P2K8
Show all »
Show » Show » 1649 186.9 No 0
EIF2AK4-002 ENSP00000453148
ENST00000559624
Q9P2K8
Show all »
Show » Show » 616 69.8 No 0
EIF2AK4-003 ENSP00000453575
ENST00000560855
Show » Show » 1427 161.1 No 0
EIF2AK4-009 ENSP00000454210
ENST00000558823
Show » 80 9.5 No 0
EIF2AK4-010 ENSP00000453968
ENST00000560648
H0YND8
Show all »
Show » Show » 136 15.1 No 0