DUT

GENE INFORMATION

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Gene name

DUT (HGNC Symbol)

Synonyms

dUTPase

Description

Deoxyuridine triphosphatase (HGNC Symbol)

Entrez gene summary

This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q21.1

Chromosome location (bp)

48331011 - 48343373

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000128951 (version 78.38)

Entrez gene

1854

UniProt

P33316 (UniProt - Evidence at protein level)

neXtProt

NX_P33316

Antibodypedia

DUT antibodies
 

PROTEIN VIEW

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DUT-001
 
DUT-003
 
DUT-004
 
DUT-006
 
DUT-007
 
DUT-008
 
DUT-009
 
DUT-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DUT-001 ENSP00000370376
ENST00000331200
P33316
Show all »
Show » Show » 252 26.6 No 0
DUT-003 ENSP00000405160
ENST00000455976
P33316
Show all »
Show » Show » 164 17.7 No 0
DUT-004 ENSP00000454041
ENST00000559540
H0YNJ9
Show all »
Show » Show » 143 15.5 No 0
DUT-006 ENSP00000453717
ENST00000558813
P33316
Show all »
Show » Show » 141 15.4 No 0
DUT-007 ENSP00000453667
ENST00000559935
H0YMM5
Show all »
Show » Show » 133 14.3 No 0
DUT-008 ENSP00000454183
ENST00000559416
H0YNW5
Show all »
Show » Show » 167 17.8 No 0
DUT-009 ENSP00000452749
ENST00000558472
H0YKC5
Show all »
Show » Show » 221 23.7 No 0
DUT-010 ENSP00000453683
ENST00000558367
H0YMP1
Show all »
Show » Show » 107 11.9 No 0