CCNT1

GENE INFORMATION

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Gene name

CCNT1 (HGNC Symbol)

Synonyms

CCNT, CYCT1, HIVE1

Description

Cyclin T1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

Chromosome

12

Cytoband

Chromosome location (bp)

48688458 - 48716998

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000129315 (version 78.38)

Entrez gene

904

UniProt

O60563 (UniProt - Evidence at protein level)

neXtProt

NX_O60563

Antibodypedia

CCNT1 antibodies
 

PROTEIN VIEW

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CCNT1-001
 
CCNT1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCNT1-001 ENSP00000261900
ENST00000261900
O60563
Show all »
Show » Show » 726 80.7 No 0
CCNT1-201 ENSP00000481035
ENST00000618666
O60563
Show all »
Show » Show » 184 21.2 No 0