KLK8

GENE INFORMATION

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Gene name

KLK8 (HGNC Symbol)

Synonyms

HNP, neuropsin, ovasin, PRSS19, TADG14

Description

Kallikrein-related peptidase 8 (HGNC Symbol)

Entrez gene summary

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Chromosome

19

Cytoband

q13.41

Chromosome location (bp)

50996007 - 51002711

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000129455 (version 78.38)

Entrez gene

11202

UniProt

O60259 (UniProt - Evidence at protein level)

neXtProt

NX_O60259

Antibodypedia

KLK8 antibodies
 

PROTEIN VIEW

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KLK8-001
 
KLK8-002
 
KLK8-004
 
KLK8-007
 
KLK8-009
 
KLK8-201
 
KLK8-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KLK8-001 ENSP00000472016
ENST00000600767
O60259
Show all »
Show » Show » 260 28 Yes 0
KLK8-002 ENSP00000375682
ENST00000391806
O60259
Show all »
Show » Show » 305 33 Yes 0
KLK8-004 ENSP00000341555
ENST00000347619
O60259
Show all »
Show » Show » 119 12.7 Yes 0
KLK8-007 ENSP00000469278
ENST00000593490
O60259
Show all »
Show » Show » 32 3.7 Yes 0
KLK8-009 ENSP00000472273
ENST00000595238
M0R231
Show all »
Show » Show » 97 10.7 Yes 0
KLK8-201 ENSP00000291726
ENST00000291726
Show » Show » 139 14.7 No 0
KLK8-202 ENSP00000325072
ENST00000320838
O60259
Show all »
Show » Show » 32 3.7 Yes 0