TNNT3

GENE INFORMATION

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Gene name

TNNT3 (HGNC Symbol)

Synonyms

AMCD2B, DA2B, DKFZp779M2348, FSSV

Description

Troponin T type 3 (skeletal, fast) (HGNC Symbol)

Entrez gene summary

The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009]

Chromosome

11

Cytoband

p15.5

Chromosome location (bp)

1919562 - 1938706

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000130595 (version 78.38)

Entrez gene

7140

UniProt

P45378 (UniProt - Evidence at protein level)

neXtProt

NX_P45378

Antibodypedia

TNNT3 antibodies
 

PROTEIN VIEW

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TNNT3-001
 
TNNT3-002
 
TNNT3-003
 
TNNT3-004
 
TNNT3-006
 
TNNT3-007
 
TNNT3-010
 
TNNT3-011
 
TNNT3-012
 
TNNT3-014
 
TNNT3-015
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TNNT3-001 ENSP00000278317
ENST00000278317
P45378
Show all »
Show » Show » 258 30.6 No 0
TNNT3-002 ENSP00000371001
ENST00000381589
P45378
Show all »
Show » Show » 256 30.3 No 0
TNNT3-003 ENSP00000370991
ENST00000381579
P45378
Show all »
Show » Show » 250 29.7 No 0
TNNT3-004 ENSP00000370970
ENST00000381558
P45378
Show all »
Show » Show » 250 29.7 No 0
TNNT3-006 ENSP00000370969
ENST00000381557
F8WA37
Show all »
Show » Show » 244 28.9 No 0
TNNT3-007 ENSP00000415614
ENST00000453458
C9JCA5
Show all »
Show » Show » 208 25 No 0
TNNT3-010 ENSP00000380468
ENST00000397301
P45378
Show all »
Show » Show » 269 31.8 No 0
TNNT3-011 ENSP00000344870
ENST00000344578
P45378
Show all »
Show » Show » 245 29.1 No 0
TNNT3-012 ENSP00000370975
ENST00000381563
P45378
Show all »
Show » Show » 261 31 No 0
TNNT3-014 ENSP00000380471
ENST00000397304
H9KVA2
Show all »
Show » Show » 239 28.3 No 0
TNNT3-015 ENSP00000413203
ENST00000446240
C9JZN9
Show all »
Show » Show » 239 28.3 No 0