DUSP9

GENE INFORMATION

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Gene name

DUSP9 (HGNC Symbol)

Synonyms

MKP-4, MKP4

Description

Dual specificity phosphatase 9 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases, is expressed only in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus. [provided by RefSeq, Jul 2008]

Chromosome

X

Cytoband

q28

Chromosome location (bp)

153642492 - 153651326

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000130829 (version 78.38)

Entrez gene

1852

UniProt

Q99956 (UniProt - Evidence at protein level)

neXtProt

NX_Q99956

Antibodypedia

DUSP9 antibodies
 

PROTEIN VIEW

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DUSP9-001
 
DUSP9-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DUSP9-001 ENSP00000359186
ENST00000370167
Q99956
Show all »
Show » Show » 384 41.9 No 0
DUSP9-003 ENSP00000345853
ENST00000342782
Q99956
Show all »
Show » Show » 384 41.9 No 0