LILRB2 - Gene info - The Human Protein Atlas

Gene name

LILRB2 (HGNC Symbol)

Synonyms

CD85d, ILT4, LIR-2, LIR2, MIR-10, MIR10

Description

Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 (HGNC Symbol)

Entrez gene summary

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

q13.42

Chromosome location (bp)

54238904 - 54281184

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000131042 (version 78.38)

Entrez gene

10288

UniProt

Q8N423 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LILRB2-001

ENSP00000375628
ENST00000391748

Q8N423
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Q8N423 [Direct mapping]
Leukocyte immunoglobulin-like receptor subfamily B member 2
A2IXV5 [Target identity:100%; Query identity:100%]
MIR-10 {ECO:0000313|EMBL:AAB67711.1}

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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0002578 [negative regulation of antigen processing and presentation]
GO:0002666 [positive regulation of T cell tolerance induction]
GO:0002767 [immune response-inhibiting cell surface receptor signaling pathway]
GO:0002774 [Fc receptor mediated inhibitory signaling pathway]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006955 [immune response]
GO:0006968 [cellular defense response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008157 [protein phosphatase 1 binding]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0023029 [MHC class Ib protein binding]
GO:0032396 [inhibitory MHC class I receptor activity]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0034113 [heterotypic cell-cell adhesion]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042130 [negative regulation of T cell proliferation]
GO:0042288 [MHC class I protein binding]
GO:0045591 [positive regulation of regulatory T cell differentiation]
GO:0050776 [regulation of immune response]
GO:0050839 [cell adhesion molecule binding]
GO:0051926 [negative regulation of calcium ion transport]
GO:0071222 [cellular response to lipopolysaccharide]
GO:2001198 [regulation of dendritic cell differentiation]

597

Yes

LILRB2-003

ENSP00000375629
ENST00000391749

Q8N423
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Q8N423 [Direct mapping]
Leukocyte immunoglobulin-like receptor subfamily B member 2

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598

65.1

Yes

LILRB2-004

ENSP00000319960
ENST00000314446

Q8N423
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Q8N423 [Direct mapping]
Leukocyte immunoglobulin-like receptor subfamily B member 2
A2IXV5 [Target identity:100%; Query identity:100%]
MIR-10 {ECO:0000313|EMBL:AAB67711.1}

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597

Yes

LILRB2-005

ENSP00000375626
ENST00000391746

Q8N423
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Q8N423 [Direct mapping]
Leukocyte immunoglobulin-like receptor subfamily B member 2

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510

55.5

Yes

LILRB2-201

ENSP00000410117
ENST00000434421

Q8N423
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Q8N423 [Direct mapping]
Leukocyte immunoglobulin-like receptor subfamily B member 2

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482

LILRB2-202

ENSP00000484266
ENST00000612280

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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005515 [protein binding]

455

49.9

Yes

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.