PSME3 - Gene info - The Human Protein Atlas

PSME3

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TISSUE

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SUBCELL

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CELL LINE

CANCER

GENE INFORMATION

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Gene name	PSME3 (HGNC Symbol)
Synonyms	Ki, PA28-gamma, PA28G, REG-GAMMA
Description	Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) (HGNC Symbol)
Entrez gene summary	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
Chromosome	17
Cytoband	q21.31
Chromosome location (bp)	42824385 - 42843758
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131467 (version 78.38)
Entrez gene	10197
UniProt	P61289 (UniProt - Evidence at protein level)
neXtProt	NX_P61289
Antibodypedia	PSME3 antibodies

PROTEIN VIEW

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PSME3-001		PSME3-002		PSME3-003		PSME3-004		PSME3-006		PSME3-009		PSME3-012		PSME3-013		PSME3-015		PSME3-201		PSME3-202

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
PSME3-001	ENSP00000466794 ENST00000590720	P61289 Show all » « Hide P61289 [Direct mapping] Proteasome activator complex subunit 3 V9HWJ8 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 283 {ECO:0000313\|EMBL:ACJ13707.1} B3KQ25 [Target identity:75%; Query identity:100%] Proteasome activator complex subunit 3 {ECO:0000313\|Ensembl:ENSP00000441682}; cDNA FLJ32659 fis, clone TESTI1000045, highly similar to Proteasome activator complex subunit 3 {ECO:0000313\|EMBL:BAG51887.1} K7EKR3 [Target identity:46%; Query identity:100%] Proteasome activator complex subunit 3 {ECO:0000313\|Ensembl:ENSP00000465743} K7EPX6 [Target identity:43%; Query identity:100%] Proteasome activator complex subunit 3 {ECO:0000313\|Ensembl:ENSP00000467580} K7EMD0 [Target identity:37%; Query identity:100%] Proteasome activator complex subunit 3 {ECO:0000313\|Ensembl:ENSP00000466451}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000209 [protein polyubiquitination] GO:0000278 [mitotic cell cycle] GO:0000502 [proteasome complex] GO:0002039 [p53 binding] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006521 [regulation of cellular amino acid metabolic process] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0008537 [proteasome activator complex] GO:0010467 [gene expression] GO:0010950 [positive regulation of endopeptidase activity] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016070 [RNA metabolic process] GO:0016071 [mRNA metabolic process] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0044281 [small molecule metabolic process] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0061133 [endopeptidase activator activity] GO:0061136 [regulation of proteasomal protein catabolic process] GO:0097371 [MDM2/MDM4 family protein binding] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]	254	29.5	No	0
PSME3-002	ENSP00000293362 ENST00000293362	P61289 Show all » « Hide P61289 [Direct mapping] Proteasome activator complex subunit 3	Show » « Hide SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000209 [protein polyubiquitination] GO:0000278 [mitotic cell cycle] GO:0000502 [proteasome complex] GO:0002039 [p53 binding] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006521 [regulation of cellular amino acid metabolic process] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0008537 [proteasome activator complex] GO:0010467 [gene expression] GO:0010950 [positive regulation of endopeptidase activity] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016070 [RNA metabolic process] GO:0016071 [mRNA metabolic process] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0044281 [small molecule metabolic process] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0061133 [endopeptidase activator activity] GO:0061136 [regulation of proteasomal protein catabolic process] GO:0097371 [MDM2/MDM4 family protein binding] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]	267	30.9	No	0
PSME3-003	ENSP00000466451 ENST00000585805	K7EMD0 Show all » « Hide K7EMD0 [Target identity:100%; Query identity:100%] Proteasome activator complex subunit 3 {ECO:0000313\|Ensembl:ENSP00000466451}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0008537 [proteasome activator complex]	96	10.9	No	0
PSME3-004	ENSP00000409487 ENST00000441946	P61289 Show all » « Hide P61289 [Direct mapping] Proteasome activator complex subunit 3 A0A024R203 [Target identity:100%; Query identity:100%] Proteasome (Prosome, macropain) activator subunit 3 (PA28 gamma Ki), isoform CRA_a {ECO:0000313\|EMBL:EAW60894.1} B3KQ25 [Target identity:72%; Query identity:100%] Proteasome activator complex subunit 3 {ECO:0000313\|Ensembl:ENSP00000441682}; cDNA FLJ32659 fis, clone TESTI1000045, highly similar to Proteasome activator complex subunit 3 {ECO:0000313\|EMBL:BAG51887.1} K7EKR3 [Target identity:44%; Query identity:100%] Proteasome activator complex subunit 3 {ECO:0000313\|Ensembl:ENSP00000465743} K7EPX6 [Target identity:41%; Query identity:100%] Proteasome activator complex subunit 3 {ECO:0000313\|Ensembl:ENSP00000467580} K7EMD0 [Target identity:36%; Query identity:100%] Proteasome activator complex subunit 3 {ECO:0000313\|Ensembl:ENSP00000466451}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000209 [protein polyubiquitination] GO:0000278 [mitotic cell cycle] GO:0000502 [proteasome complex] GO:0002039 [p53 binding] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006521 [regulation of cellular amino acid metabolic process] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0008537 [proteasome activator complex] GO:0010467 [gene expression] GO:0010950 [positive regulation of endopeptidase activity] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016070 [RNA metabolic process] GO:0016071 [mRNA metabolic process] GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0044281 [small molecule metabolic process] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0061133 [endopeptidase activator activity] GO:0061136 [regulation of proteasomal protein catabolic process] GO:0097371 [MDM2/MDM4 family protein binding] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]	265	30.9	No	0
PSME3-006	ENSP00000441682 ENST00000545225	B3KQ25 Show all » « Hide B3KQ25 [Target identity:100%; Query identity:100%] Proteasome activator complex subunit 3 {ECO:0000313\|Ensembl:ENSP00000441682}; cDNA FLJ32659 fis, clone TESTI1000045, highly similar to Proteasome activator complex subunit 3 {ECO:0000313\|EMBL:BAG51887.1} K7EKR3 [Target identity:61%; Query identity:100%] Proteasome activator complex subunit 3 {ECO:0000313\|Ensembl:ENSP00000465743} K7EPX6 [Target identity:56%; Query identity:100%] Proteasome activator complex subunit 3 {ECO:0000313\|Ensembl:ENSP00000467580} K7EMD0 [Target identity:49%; Query identity:100%] Proteasome activator complex subunit 3 {ECO:0000313\|Ensembl:ENSP00000466451}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0008537 [proteasome activator complex]	193	22.5	No	0
PSME3-009	ENSP00000465743 ENST00000591152	K7EKR3 Show all » « Hide K7EKR3 [Target identity:99%; Query identity:100%] Proteasome activator complex subunit 3 {ECO:0000313\|Ensembl:ENSP00000465743} K7EPX6 [Target identity:92%; Query identity:100%] Proteasome activator complex subunit 3 {ECO:0000313\|Ensembl:ENSP00000467580} K7EMD0 [Target identity:80%; Query identity:100%] Proteasome activator complex subunit 3 {ECO:0000313\|Ensembl:ENSP00000466451}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0008537 [proteasome activator complex]	119	13.5	No	0
PSME3-012	ENSP00000468702 ENST00000592169	K7ESG5 Show all » « Hide K7ESG5 [Target identity:100%; Query identity:100%] Proteasome activator complex subunit 3 {ECO:0000313\|Ensembl:ENSP00000468702}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0008537 [proteasome activator complex]	198	23.3	No	0
PSME3-013	ENSP00000466945 ENST00000589469	K7ENH2 Show all » « Hide K7ENH2 [Target identity:100%; Query identity:100%] Proteasome activator complex subunit 3 {ECO:0000313\|Ensembl:ENSP00000466945}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008537 [proteasome activator complex]	179	20.6	No	0
PSME3-015	ENSP00000467580 ENST00000586114	K7EPX6 Show all » « Hide K7EPX6 [Target identity:99%; Query identity:100%] Proteasome activator complex subunit 3 {ECO:0000313\|Ensembl:ENSP00000467580} K7EMD0 [Target identity:86%; Query identity:100%] Proteasome activator complex subunit 3 {ECO:0000313\|Ensembl:ENSP00000466451}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0008537 [proteasome activator complex]	111	12.6	No	0
PSME3-201	ENSP00000438237 ENST00000541124	K9J957 Show all » « Hide K9J957 [Target identity:100%; Query identity:100%] REG gamma-3 variant {ECO:0000313\|EMBL:ACO54885.1} K7ENH2 [Target identity:77%; Query identity:100%] Proteasome activator complex subunit 3 {ECO:0000313\|Ensembl:ENSP00000466945}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008537 [proteasome activator complex]	231	26.9	No	0
PSME3-202	ENSP00000478159 ENST00000622892		Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0008537 [proteasome activator complex]	170	19.9	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.