TOP2A

GENE INFORMATION

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Gene name

TOP2A (HGNC Symbol)

Synonyms

TOP2

Description

Topoisomerase (DNA) II alpha 170kDa (HGNC Symbol)

Entrez gene summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]

Chromosome

17

Cytoband

q21.2

Chromosome location (bp)

40388516 - 40417950

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000131747 (version 78.38)

Entrez gene

7153

UniProt

P11388 (UniProt - Evidence at protein level)

neXtProt

NX_P11388

Antibodypedia

TOP2A antibodies
 

PROTEIN VIEW

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TOP2A-001
 
TOP2A-003
 
TOP2A-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TOP2A-001 ENSP00000411532
ENST00000423485
P11388
Show all »
Show » Show » 1531 174.4 No 0
TOP2A-003 ENSP00000462908
ENST00000581055
J3KTB7
Show all »
Show » Show » 147 17.1 No 0
TOP2A-006 ENSP00000464055
ENST00000577541
J3QR57
Show all »
Show » Show » 27 3.1 No 0