RFX1

GENE INFORMATION

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Gene name

RFX1 (HGNC Symbol)

Synonyms

EF-C

Description

Regulatory factor X, 1 (influences HLA class II expression) (HGNC Symbol)

Entrez gene summary

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

p13.12

Chromosome location (bp)

13961538 - 14007039

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000132005 (version 78.38)

Entrez gene

5989

UniProt

P22670 (UniProt - Evidence at protein level)

neXtProt

NX_P22670

Antibodypedia

RFX1 antibodies
 

PROTEIN VIEW

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RFX1-001
 
RFX1-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RFX1-001 ENSP00000254325
ENST00000254325
P22670
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Show » Show » 979 104.8 No 0
RFX1-005 ENSP00000464960
ENST00000588885
K7EIZ8
Show all »
Show » 158 16.1 No 0