TRIM21

GENE INFORMATION

? »

Gene name

TRIM21 (HGNC Symbol)

Synonyms

RNF81, Ro/SSA, RO52, SSA1

Description

Tripartite motif containing 21 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

p15.4

Chromosome location (bp)

4384897 - 4393696

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000132109 (version 78.38)

Entrez gene

6737

UniProt

P19474 (UniProt - Evidence at protein level)

neXtProt

NX_P19474

Antibodypedia

TRIM21 antibodies
 

PROTEIN VIEW

? »
 
 
 
TRIM21-001
 
TRIM21-003
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TRIM21-001 ENSP00000254436
ENST00000254436
P19474
Show all »
Show » Show » 475 54.2 No 0
TRIM21-003 ENSP00000434053
ENST00000533692
Show » 90 10.1 No 0