TRIM5

GENE INFORMATION

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Gene name

TRIM5 (HGNC Symbol)

Synonyms

RNF88, TRIM5alpha

Description

Tripartite motif containing 5 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]

Chromosome

11

Cytoband

p15.4

Chromosome location (bp)

5663557 - 5938619

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000132256 (version 78.38)

Entrez gene

85363

UniProt

Q9C035 (UniProt - Evidence at protein level)

neXtProt

NX_Q9C035

Antibodypedia

TRIM5 antibodies
 

PROTEIN VIEW

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TRIM5-001
 
TRIM5-003
 
TRIM5-004
 
TRIM5-009
 
TRIM5-012
 
TRIM5-013
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TRIM5-001 ENSP00000369373
ENST00000380034
Q9C035
Show all »
Show » Show » 493 56.3 No 0
TRIM5-003 ENSP00000369366
ENST00000380027
Q9C035
Show all »
Show » Show » 326 37.7 No 0
TRIM5-004 ENSP00000380058
ENST00000396847
Q9C035
Show all »
Show » Show » 347 40.1 No 0
TRIM5-009 ENSP00000398196
ENST00000438025
Show » 187 21.3 No 0
TRIM5-012 ENSP00000388031
ENST00000412903
E7EQQ5
Show all »
Show » Show » 209 24.2 No 0
TRIM5-013 ENSP00000388150
ENST00000419850
C9JWN8
Show all »
Show » Show » 72 8 No 0