PER2

GENE INFORMATION

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Gene name

PER2 (HGNC Symbol)

Synonyms

KIAA0347

Description

Period circadian clock 2 (HGNC Symbol)

Entrez gene summary

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014]

Chromosome

2

Cytoband

q37.3

Chromosome location (bp)

238244038 - 238290102

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000132326 (version 78.38)

Entrez gene

8864

UniProt

O15055 (UniProt - Evidence at protein level)

neXtProt

NX_O15055

Antibodypedia

PER2 antibodies
 

PROTEIN VIEW

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PER2-001
 
PER2-002
 
PER2-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PER2-001 ENSP00000254657
ENST00000254657
O15055
Show all »
Show » Show » 1255 136.6 No 0
PER2-002 ENSP00000348013
ENST00000355768
O15055
Show all »
Show » Show » 404 45.2 No 0
PER2-004 ENSP00000405891
ENST00000431832
E9PD89
Show all »
Show » 109 11.6 No 0