ITGB4

GENE INFORMATION

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Gene name

ITGB4 (HGNC Symbol)

Synonyms

CD104

Description

Integrin, beta 4 (HGNC Symbol)

Entrez gene summary

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q25.1

Chromosome location (bp)

75721328 - 75757818

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000132470 (version 78.38)

Entrez gene

3691

UniProt

P16144 (UniProt - Evidence at protein level)

neXtProt

NX_P16144

Antibodypedia

ITGB4 antibodies
 

PROTEIN VIEW

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ITGB4-001
 
ITGB4-002
 
ITGB4-003
 
ITGB4-007
 
ITGB4-008
 
ITGB4-011
 
ITGB4-012
 
ITGB4-014
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ITGB4-001 ENSP00000200181
ENST00000200181
P16144
Show all »
Show » Show » 1822 202.2 Yes 1
ITGB4-002 ENSP00000405536
ENST00000450894
P16144
Show all »
Show » Show » 1752 195 Yes 1
ITGB4-003 ENSP00000400217
ENST00000449880
P16144
Show all »
Show » Show » 1805 200.7 Yes 1
ITGB4-007 ENSP00000463651
ENST00000579662
P16144
Show all »
Show » Show » 1752 195 Yes 1
ITGB4-008 ENSP00000463788
ENST00000582629
J3QQL2
Show all »
Show » Show » 114 12.7 No 0
ITGB4-011 ENSP00000464473
ENST00000583327
J3QS11
Show all »
Show » Show » 216 24 No 0
ITGB4-012 ENSP00000464259
ENST00000584939
Show » Show » 201 21.7 No 0
ITGB4-014 ENSP00000462494
ENST00000578318
Show » 63 6.7 No 0