PRMT7 - Gene info - The Human Protein Atlas

Gene name

PRMT7 (HGNC Symbol)

Synonyms

FLJ10640, KIAA1933

Description

Protein arginine methyltransferase 7 (HGNC Symbol)

Entrez gene summary

Arginine methylation is an apparently irreversible protein modification catalyzed by arginine methyltransferases, such as PMT7, using S-adenosylmethionine (AdoMet) as the methyl donor. Arginine methylation is implicated in signal transduction, RNA transport, and RNA splicing (Miranda et al., 2004 [PubMed 15044439]).[supplied by OMIM, Mar 2008]

Chromosome

Cytoband

q22.1

Chromosome location (bp)

68310974 - 68358563

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000132600 (version 78.38)

Entrez gene

54496

UniProt

Q9NVM4 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRMT7-001

ENSP00000343103
ENST00000339507

Q9NVM4
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Q9NVM4 [Direct mapping]
Protein arginine N-methyltransferase 7
A0A024R726 [Target identity:100%; Query identity:100%]
Protein arginine methyltransferase 7, isoform CRA_a {ECO:0000313|EMBL:EAW83230.1}
A0A024R6Z2 [Target identity:88%; Query identity:100%]
Protein arginine methyltransferase 7, isoform CRA_b {ECO:0000313|EMBL:EAW83227.1}
H3BPZ8 [Target identity:32%; Query identity:100%]
Protein arginine N-methyltransferase 7 {ECO:0000313|Ensembl:ENSP00000455538}
H3BSS9 [Target identity:24%; Query identity:100%]
Protein arginine N-methyltransferase 7 {ECO:0000313|Ensembl:ENSP00000456848}
H3BRQ9 [Target identity:15%; Query identity:100%]
Protein arginine N-methyltransferase 7 {ECO:0000313|Ensembl:ENSP00000456364}
H3BNS2 [Target identity:11%; Query identity:100%]
Protein arginine N-methyltransferase 7 {ECO:0000313|Ensembl:ENSP00000454980}
H3BRD3 [Target identity:10%; Query identity:100%]
Protein arginine N-methyltransferase 7 {ECO:0000313|Ensembl:ENSP00000456190}

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Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000387 [spliceosomal snRNP assembly]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0008276 [protein methyltransferase activity]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity]
GO:0016277 [[myelin basic protein]-arginine N-methyltransferase activity]
GO:0016571 [histone methylation]
GO:0018216 [peptidyl-arginine methylation]
GO:0019918 [peptidyl-arginine methylation, to symmetrical-dimethyl arginine]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0030154 [cell differentiation]
GO:0034969 [histone arginine methylation]
GO:0035241 [protein-arginine omega-N monomethyltransferase activity]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
GO:0035243 [protein-arginine omega-N symmetric methyltransferase activity]
GO:0042393 [histone binding]
GO:0043021 [ribonucleoprotein complex binding]
GO:0043046 [DNA methylation involved in gamete generation]
GO:0043393 [regulation of protein binding]
GO:0043985 [histone H4-R3 methylation]
GO:0044020 [histone methyltransferase activity (H4-R3 specific)]

692

78.5

PRMT7-014

ENSP00000414716
ENST00000449359

Q9NVM4
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Q9NVM4 [Direct mapping]
Protein arginine N-methyltransferase 7

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GO:0000387 [spliceosomal snRNP assembly]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity]
GO:0016277 [[myelin basic protein]-arginine N-methyltransferase activity]
GO:0016571 [histone methylation]
GO:0018216 [peptidyl-arginine methylation]
GO:0019918 [peptidyl-arginine methylation, to symmetrical-dimethyl arginine]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0030154 [cell differentiation]
GO:0034969 [histone arginine methylation]
GO:0035241 [protein-arginine omega-N monomethyltransferase activity]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
GO:0035243 [protein-arginine omega-N symmetric methyltransferase activity]
GO:0042393 [histone binding]
GO:0043021 [ribonucleoprotein complex binding]
GO:0043046 [DNA methylation involved in gamete generation]
GO:0043393 [regulation of protein binding]
GO:0044020 [histone methyltransferase activity (H4-R3 specific)]

642

73.2

PRMT7-019

ENSP00000456190
ENST00000565745

H3BRD3
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H3BRD3 [Target identity:100%; Query identity:100%]
Protein arginine N-methyltransferase 7 {ECO:0000313|Ensembl:ENSP00000456190}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

8.4

PRMT7-023

ENSP00000454980
ENST00000566657

H3BNS2
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H3BNS2 [Target identity:100%; Query identity:100%]
Protein arginine N-methyltransferase 7 {ECO:0000313|Ensembl:ENSP00000454980}
H3BRD3 [Target identity:90%; Query identity:100%]
Protein arginine N-methyltransferase 7 {ECO:0000313|Ensembl:ENSP00000456190}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

9.1

PRMT7-027

ENSP00000455538
ENST00000569571

H3BPZ8
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H3BPZ8 [Target identity:100%; Query identity:100%]
Protein arginine N-methyltransferase 7 {ECO:0000313|Ensembl:ENSP00000455538}
H3BSS9 [Target identity:75%; Query identity:100%]
Protein arginine N-methyltransferase 7 {ECO:0000313|Ensembl:ENSP00000456848}
H3BRQ9 [Target identity:48%; Query identity:100%]
Protein arginine N-methyltransferase 7 {ECO:0000313|Ensembl:ENSP00000456364}
H3BNS2 [Target identity:35%; Query identity:100%]
Protein arginine N-methyltransferase 7 {ECO:0000313|Ensembl:ENSP00000454980}
H3BRD3 [Target identity:32%; Query identity:100%]
Protein arginine N-methyltransferase 7 {ECO:0000313|Ensembl:ENSP00000456190}

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SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005737 [cytoplasm]
GO:0006479 [protein methylation]
GO:0008276 [protein methyltransferase activity]

223

24.8

PRMT7-030

ENSP00000456848
ENST00000569047

H3BSS9
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H3BSS9 [Target identity:100%; Query identity:100%]
Protein arginine N-methyltransferase 7 {ECO:0000313|Ensembl:ENSP00000456848}
H3BRQ9 [Target identity:63%; Query identity:100%]
Protein arginine N-methyltransferase 7 {ECO:0000313|Ensembl:ENSP00000456364}
H3BNS2 [Target identity:47%; Query identity:100%]
Protein arginine N-methyltransferase 7 {ECO:0000313|Ensembl:ENSP00000454980}
H3BRD3 [Target identity:42%; Query identity:100%]
Protein arginine N-methyltransferase 7 {ECO:0000313|Ensembl:ENSP00000456190}

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SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005737 [cytoplasm]
GO:0006479 [protein methylation]
GO:0008276 [protein methyltransferase activity]

169

18.8

PRMT7-201

ENSP00000409324
ENST00000441236

Q9NVM4
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GO:0000387 [spliceosomal snRNP assembly]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0008276 [protein methyltransferase activity]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity]
GO:0016277 [[myelin basic protein]-arginine N-methyltransferase activity]
GO:0016571 [histone methylation]
GO:0018216 [peptidyl-arginine methylation]
GO:0019918 [peptidyl-arginine methylation, to symmetrical-dimethyl arginine]
GO:0019919 [peptidyl-arginine methylation, to asymmetrical-dimethyl arginine]
GO:0030154 [cell differentiation]
GO:0034969 [histone arginine methylation]
GO:0035241 [protein-arginine omega-N monomethyltransferase activity]
GO:0035242 [protein-arginine omega-N asymmetric methyltransferase activity]
GO:0035243 [protein-arginine omega-N symmetric methyltransferase activity]
GO:0042393 [histone binding]
GO:0043021 [ribonucleoprotein complex binding]
GO:0043046 [DNA methylation involved in gamete generation]
GO:0043393 [regulation of protein binding]
GO:0044020 [histone methyltransferase activity (H4-R3 specific)]

692

78.5

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.