PTPRA

GENE INFORMATION

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Gene name

PTPRA (HGNC Symbol)

Synonyms

HLPR, HPTPA, LRP, PTPA, PTPRL2, RPTPA

Description

Protein tyrosine phosphatase, receptor type, A (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

p13

Chromosome location (bp)

2864184 - 3039076

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000132670 (version 78.38)

Entrez gene

5786

UniProt

P18433 (UniProt - Evidence at protein level)

neXtProt

NX_P18433

Antibodypedia

PTPRA antibodies
 

PROTEIN VIEW

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PTPRA-001
 
PTPRA-002
 
PTPRA-003
 
PTPRA-004
 
PTPRA-007
 
PTPRA-008
 
PTPRA-201
 
PTPRA-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTPRA-001 ENSP00000216877
ENST00000216877
P18433
Show all »
Show » Show » 793 89.7 Yes 1
PTPRA-002 ENSP00000314568
ENST00000318266
P18433
Show all »
Show » Show » 793 89.7 Yes 1
PTPRA-003 ENSP00000369756
ENST00000380393
P18433
Show all »
Show » Show » 802 90.7 Yes 1
PTPRA-004 ENSP00000414089
ENST00000455631
Q5JWG0
Show all »
Show » 253 27.3 Yes 1
PTPRA-007 ENSP00000394132
ENST00000430705
Q5JWG2
Show all »
Show » 175 18.4 Yes 1
PTPRA-008 ENSP00000390775
ENST00000431048
Q5JWG3
Show all »
Show » 138 14.3 Yes 0
PTPRA-201 ENSP00000348468
ENST00000356147
P18433
Show all »
Show » Show » 793 89.7 Yes 1
PTPRA-202 ENSP00000382787
ENST00000399903
P18433
Show all »
Show » Show » 802 90.7 Yes 1