CCNA1

GENE INFORMATION

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Gene name

CCNA1 (HGNC Symbol)

Synonyms

CT146

Description

Cyclin A1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

13

Cytoband

q13.3

Chromosome location (bp)

36431830 - 36442882

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000133101 (version 78.38)

Entrez gene

8900

UniProt

P78396 (UniProt - Evidence at protein level)

neXtProt

NX_P78396

Antibodypedia

CCNA1 antibodies
 

PROTEIN VIEW

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CCNA1-001
 
CCNA1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCNA1-001 ENSP00000255465
ENST00000255465
P78396
Show all »
Show » Show » 465 52.4 No 0
CCNA1-201 ENSP00000400666
ENST00000440264
P78396
Show all »
Show » Show » 421 47.5 No 0