SPINK5

GENE INFORMATION

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Gene name

SPINK5 (HGNC Symbol)

Synonyms

DKFZp686K19184, FLJ21544, FLJ97536, FLJ97596, FLJ99794, LEKTI, LETKI, NETS, NS, VAKTI

Description

Serine peptidase inhibitor, Kazal type 5 (HGNC Symbol)

Entrez gene summary

This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The inhibitor may play a role in skin and hair morphogenesis and anti-inflammatory and/or antimicrobial protection of mucous epithelia. Mutations may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q32

Chromosome location (bp)

148025683 - 148137289

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000133710 (version 78.38)

Entrez gene

11005

UniProt

Q9NQ38 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NQ38

Antibodypedia

SPINK5 antibodies
 

PROTEIN VIEW

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SPINK5-001
 
SPINK5-002
 
SPINK5-003
 
SPINK5-008
 
SPINK5-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SPINK5-001 ENSP00000256084
ENST00000256084
Q9NQ38
Show all »
Show » Show » 1064 120.7 Yes 0
SPINK5-002 ENSP00000381472
ENST00000398454
Q9NQ38
Show all »
Show » Show » 916 104 Yes 0
SPINK5-003 ENSP00000352936
ENST00000359874
Q9NQ38
Show all »
Show » Show » 1094 124.1 Yes 0
SPINK5-008 ENSP00000421519
ENST00000508733
E7EWP9
Show all »
Show » Show » 869 98.5 Yes 0
SPINK5-011 ENSP00000430264
ENST00000521206
E5RG22
Show all »
Show » 68 7.6 Yes 0