CFHR4

GENE INFORMATION

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Gene name

CFHR4 (HGNC Symbol)

Synonyms

CFHL4, FHR-4, FHR4

Description

Complement factor H-related 4 (HGNC Symbol)

Entrez gene summary

This gene is a member of the complement factor H (CFH) gene family, and encodes one of the 5 CFH-related (CFHR) proteins. These 5 genes are closely linked to the CFH gene on chromosome 1q31-q32. The CFHRs are secreted plasma proteins synthesized primarily by the hepatocytes, and composed of highly-related short consensus repeats (SCRs). This protein enhances the cofactor activity of CFH, and is involved in complement regulation. It can associate with lipoproteins and may play a role in lipid metabolism. Alternatively spliced transcript variants encoding different isoforms (varying in the number of SCRs) have been described for this gene. [provided by RefSeq, Jan 2011]

Chromosome

1

Cytoband

q31.3

Chromosome location (bp)

196850241 - 196918972

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000134365 (version 78.38)

Entrez gene

10877

UniProt

Q92496 (UniProt - Evidence at protein level)

neXtProt

NX_Q92496

Antibodypedia

CFHR4 antibodies
 

PROTEIN VIEW

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CFHR4-001
 
CFHR4-002
 
CFHR4-003
 
CFHR4-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CFHR4-001 ENSP00000356388
ENST00000367418
Q92496
Show all »
Show » Show » 331 37.3 Yes 0
CFHR4-002 ENSP00000251424
ENST00000251424
Q92496
Show all »
Show » Show » 331 37.3 Yes 0
CFHR4-003 ENSP00000356386
ENST00000367416
Q92496
Show all »
Show » Show » 577 65.2 Yes 0
CFHR4-004 ENSP00000477162
ENST00000608469
V9GYX2
Show all »
Show » 201 22.5 No 0