CFHR5

GENE INFORMATION

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Gene name

CFHR5 (HGNC Symbol)

Synonyms

CFHL5, FHR-5, FHR5

Description

Complement factor H-related 5 (HGNC Symbol)

Entrez gene summary

This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). [provided by RefSeq, Jan 2010]

Chromosome

1

Cytoband

q31.3

Chromosome location (bp)

196977556 - 197009674

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000134389 (version 78.38)

Entrez gene

81494

UniProt

Q9BXR6 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BXR6

Antibodypedia

CFHR5 antibodies
 

PROTEIN VIEW

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CFHR5-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CFHR5-001 ENSP00000256785
ENST00000256785
Q9BXR6
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