YARS

GENE INFORMATION

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Gene name

YARS (HGNC Symbol)

Synonyms

tyrRS, YRS, YTS

Description

Tyrosyl-tRNA synthetase (HGNC Symbol)

Entrez gene summary

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p35.1

Chromosome location (bp)

32775237 - 32818153

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000134684 (version 78.38)

Entrez gene

8565

UniProt

P54577 (UniProt - Evidence at protein level)

neXtProt

NX_P54577

Antibodypedia

YARS antibodies
 

PROTEIN VIEW

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YARS-001
 
YARS-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

YARS-001 ENSP00000362576
ENST00000373477
P54577
Show all »
Show » Show » 528 59.1 No 0
YARS-201 ENSP00000484192
ENST00000616261
P54577
Show all »
Show » Show » 388 43.9 No 0