HAVCR2

GENE INFORMATION

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Gene name

HAVCR2 (HGNC Symbol)

Synonyms

FLJ14428, Tim-3, TIM3, TIMD3

Description

Hepatitis A virus cellular receptor 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]

Chromosome

5

Cytoband

q33.3

Chromosome location (bp)

157085832 - 157142869

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000135077 (version 78.38)

Entrez gene

84868

UniProt

Q8TDQ0 (UniProt - Evidence at protein level)

neXtProt

NX_Q8TDQ0

Antibodypedia

HAVCR2 antibodies
 

PROTEIN VIEW

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HAVCR2-001
 
HAVCR2-004
 
HAVCR2-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HAVCR2-001 ENSP00000312002
ENST00000307851
Q8TDQ0
Show all »
Show » Show » 301 33.4 Yes 1
HAVCR2-004 ENSP00000430873
ENST00000522593
E5RHN3
Show all »
Show » Show » 273 30.3 Yes 1
HAVCR2-007 ENSP00000430328
ENST00000524219
E5RFR4
Show all »
Show » 74 8.2 No 0