MAP3K7 - Gene info - The Human Protein Atlas

Gene name

MAP3K7 (HGNC Symbol)

Synonyms

MEKK7, TAK1

Description

Mitogen-activated protein kinase kinase kinase 7 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

q15

Chromosome location (bp)

90513573 - 90587045

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000135341 (version 78.38)

Entrez gene

6885

UniProt

O43318 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP3K7-001

ENSP00000358338
ENST00000369332

O43318
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O43318 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 7
Q9UG54 [Target identity:44%; Query identity:100%]
Mitogen-activated protein kinase kinase kinase 7 {ECO:0000313|Ensembl:ENSP00000358326}; Putative uncharacterized protein DKFZp586F0420 {ECO:0000313|EMBL:CAB43687.2}

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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0000287 [magnesium ion binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002726 [positive regulation of T cell cytokine production]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007250 [activation of NF-kappaB-inducing kinase activity]
GO:0007252 [I-kappaB phosphorylation]
GO:0007254 [JNK cascade]
GO:0008385 [IkappaB kinase complex]
GO:0010008 [endosome membrane]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043966 [histone H3 acetylation]
GO:0045087 [innate immune response]
GO:0050852 [T cell receptor signaling pathway]
GO:0050870 [positive regulation of T cell activation]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0097110 [scaffold protein binding]

579

64.2

MAP3K7-002

ENSP00000358335
ENST00000369329

O43318
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O43318 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 7

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GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0000287 [magnesium ion binding]
GO:0001525 [angiogenesis]
GO:0001841 [neural tube formation]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002726 [positive regulation of T cell cytokine production]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007250 [activation of NF-kappaB-inducing kinase activity]
GO:0007252 [I-kappaB phosphorylation]
GO:0007254 [JNK cascade]
GO:0008385 [IkappaB kinase complex]
GO:0010008 [endosome membrane]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043966 [histone H3 acetylation]
GO:0045087 [innate immune response]
GO:0046330 [positive regulation of JNK cascade]
GO:0050852 [T cell receptor signaling pathway]
GO:0050870 [positive regulation of T cell activation]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0097110 [scaffold protein binding]
GO:1902443 [negative regulation of ripoptosome assembly involved in necroptotic process]
GO:2000377 [regulation of reactive oxygen species metabolic process]
GO:2001234 [negative regulation of apoptotic signaling pathway]

606

67.2

MAP3K7-003

ENSP00000358331
ENST00000369325

O43318
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O43318 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 7

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GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0000287 [magnesium ion binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002726 [positive regulation of T cell cytokine production]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007250 [activation of NF-kappaB-inducing kinase activity]
GO:0007252 [I-kappaB phosphorylation]
GO:0007254 [JNK cascade]
GO:0008385 [IkappaB kinase complex]
GO:0010008 [endosome membrane]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043966 [histone H3 acetylation]
GO:0045087 [innate immune response]
GO:0050852 [T cell receptor signaling pathway]
GO:0050870 [positive regulation of T cell activation]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0097110 [scaffold protein binding]

518

56.7

MAP3K7-004

ENSP00000358333
ENST00000369327

O43318
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O43318 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 7

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GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0000287 [magnesium ion binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002726 [positive regulation of T cell cytokine production]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007250 [activation of NF-kappaB-inducing kinase activity]
GO:0007252 [I-kappaB phosphorylation]
GO:0007254 [JNK cascade]
GO:0008385 [IkappaB kinase complex]
GO:0010008 [endosome membrane]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043966 [histone H3 acetylation]
GO:0045087 [innate immune response]
GO:0050852 [T cell receptor signaling pathway]
GO:0050870 [positive regulation of T cell activation]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0097110 [scaffold protein binding]

491

53.7

MAP3K7-006

ENSP00000358326
ENST00000369320

Q9UG54
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Q9UG54 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase kinase kinase 7 {ECO:0000313|Ensembl:ENSP00000358326}; Putative uncharacterized protein DKFZp586F0420 {ECO:0000313|EMBL:CAB43687.2}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

260

28.9

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.