LECT1

GENE INFORMATION

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Gene name

LECT1 (HGNC Symbol)

Synonyms

BRICD3, CHM-I, CHM1, chondromodulin, MYETS1

Description

Leukocyte cell derived chemotaxin 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

13

Cytoband

q14.3

Chromosome location (bp)

52703264 - 52739812

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136110 (version 78.38)

Entrez gene

11061

UniProt

O75829 (UniProt - Evidence at protein level)

neXtProt

NX_O75829

Antibodypedia

LECT1 antibodies
 

PROTEIN VIEW

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LECT1-001
 
LECT1-002
 
LECT1-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LECT1-001 ENSP00000367198
ENST00000377962
O75829
Show all »
Show » Show » 334 37.1 No 1
LECT1-002 ENSP00000396035
ENST00000431550
E9PKI9
Show all »
Show » 129 14.1 No 0
LECT1-003 ENSP00000388576
ENST00000448904
O75829
Show all »
Show » Show » 333 37 No 1