SUCLA2

GENE INFORMATION

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Gene name

SUCLA2

Synonyms

Description

Succinate-CoA ligase, ADP-forming, beta subunit (HGNC Symbol)

Entrez gene summary

Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008]

Chromosome

13

Cytoband

q14.2

Chromosome location (bp)

47936487 - 48001326

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136143 (version 78.38)

Entrez gene

8803

UniProt

Q9P2R7 (UniProt - Evidence at protein level)

neXtProt

NX_Q9P2R7

Antibodypedia

SUCLA2 antibodies
 

PROTEIN VIEW

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SUCLA2-001
 
SUCLA2-009
 
SUCLA2-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SUCLA2-001 ENSP00000367923
ENST00000378654
Q9P2R7
Show all »
Show » Show » 463 50.3 No 0
SUCLA2-009 ENSP00000415091
ENST00000433022
Q5T9Q8
Show all »
Show » Show » 154 17.1 No 0
SUCLA2-010 ENSP00000392771
ENST00000434484
Q5T9Q5
Show all »
Show » Show » 298 32 No 0