CSH1

GENE INFORMATION

? »

Gene name

CSH1 (HGNC Symbol)

Synonyms

CSA, CSMT, FLJ75407, hCS-A, PL

Description

Chorionic somatomammotropin hormone 1 (placental lactogen) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q23.3

Chromosome location (bp)

63894909 - 63896661

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136488 (version 78.38)

Entrez gene

1442

UniProt

P0DML2 (UniProt - Evidence at protein level)

neXtProt

NX_P0DML2

Antibodypedia

CSH1 antibodies
 

PROTEIN VIEW

? »
 
 
 
CSH1-001
 
CSH1-003
 
CSH1-201
 
CSH1-202
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CSH1-001 ENSP00000316416
ENST00000316193
P0DML2
Show all »
Show » Show » 217 25 Yes 0
CSH1-003 ENSP00000333268
ENST00000329882
A6NFB4
Show all »
Show » Show » 256 28.8 Yes 0
CSH1-201 ENSP00000402517
ENST00000453363
B1A4H2
Show all »
Show » Show » 122 13.9 Yes 0
CSH1-202 ENSP00000478652
ENST00000610991
Q7KZ35
Show all »
Show » Show » 128 15 No 0