MDC1

GENE INFORMATION

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Gene name

MDC1 (HGNC Symbol)

Synonyms

Em:AB023051.5, KIAA0170, NFBD1

Description

Mediator of DNA-damage checkpoint 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p21.33

Chromosome location (bp)

30699807 - 30717889

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137337 (version 78.38)

Entrez gene

9656

UniProt

Q14676 (UniProt - Evidence at protein level)

neXtProt

NX_Q14676

Antibodypedia

MDC1 antibodies
 

PROTEIN VIEW

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MDC1-001
 
MDC1-002
 
MDC1-003
 
MDC1-004
 
MDC1-006
 
MDC1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MDC1-001 ENSP00000365588
ENST00000376406
Q14676
Show all »
Show » Show » 2089 226.7 No 0
MDC1-002 ENSP00000396989
ENST00000425072
A2AB07
Show all »
Show » Show » 127 14.2 No 0
MDC1-003 ENSP00000400979
ENST00000416571
A2AB05
Show all »
Show » Show » 162 18.2 No 0
MDC1-004 ENSP00000411310
ENST00000422266
A2AB06
Show all »
Show » Show » 113 12.5 No 0
MDC1-006 ENSP00000408962
ENST00000417033
Show » 306 32.8 No 0
MDC1-201 ENSP00000483601
ENST00000613547
A1Z5I8
Show all »
Show » Show » 142 15.2 No 0