TLR2

GENE INFORMATION

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Gene name

TLR2 (HGNC Symbol)

Synonyms

CD282, TIL4

Description

Toll-like receptor 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q31.3

Chromosome location (bp)

153701500 - 153705699

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137462 (version 78.38)

Entrez gene

7097

UniProt

O60603 (UniProt - Evidence at protein level)

neXtProt

NX_O60603

Antibodypedia

TLR2 antibodies
 

PROTEIN VIEW

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TLR2-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TLR2-001 ENSP00000260010
ENST00000260010
O60603
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