MMP20

GENE INFORMATION

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Gene name

MMP20

Synonyms

Description

Matrix metallopeptidase 20 (HGNC Symbol)

Entrez gene summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. [provided by RefSeq, Aug 2011]

Chromosome

11

Cytoband

q22.2

Chromosome location (bp)

102576835 - 102625332

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137674 (version 78.38)

Entrez gene

9313

UniProt

O60882 (UniProt - Evidence at protein level)

neXtProt

NX_O60882

Antibodypedia

MMP20 antibodies
 

PROTEIN VIEW

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MMP20-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MMP20-001 ENSP00000260228
ENST00000260228
O60882
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