MAP2K5 - Gene info - The Human Protein Atlas

Gene name

MAP2K5 (HGNC Symbol)

Synonyms

HsT17454, MAPKK5, MEK5, PRKMK5

Description

Mitogen-activated protein kinase kinase 5 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]

Chromosome

Cytoband

q23

Chromosome location (bp)

67542709 - 67807123

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137764 (version 78.38)

Entrez gene

5607

UniProt

Q13163 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP2K5-001

ENSP00000178640
ENST00000178640

Q13163
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Q13163 [Direct mapping]
Dual specificity mitogen-activated protein kinase kinase 5
A0A024R5Y2 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase kinase 5, isoform CRA_a {ECO:0000313|EMBL:EAW77801.1}
H7BZL1 [Target identity:28%; Query identity:100%]
Dual-specificity mitogen-activated protein kinase kinase 5 {ECO:0000313|Ensembl:ENSP00000390196}

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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007507 [heart development]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030307 [positive regulation of cell growth]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045415 [negative regulation of interleukin-8 biosynthetic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051247 [positive regulation of protein metabolic process]
GO:0060761 [negative regulation of response to cytokine stimulus]
GO:0070375 [ERK5 cascade]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071499 [cellular response to laminar fluid shear stress]
GO:0090051 [negative regulation of cell migration involved in sprouting angiogenesis]
GO:2000342 [negative regulation of chemokine (C-X-C motif) ligand 2 production]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]

448

50.1

MAP2K5-002

ENSP00000342101
ENST00000340972

A6NK28
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A6NK28 [Target identity:100%; Query identity:100%]
Dual-specificity mitogen-activated protein kinase kinase 5 {ECO:0000313|Ensembl:ENSP00000342101}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]

258

29.2

MAP2K5-003

ENSP00000390196
ENST00000439036

H7BZL1
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H7BZL1 [Target identity:100%; Query identity:100%]
Dual-specificity mitogen-activated protein kinase kinase 5 {ECO:0000313|Ensembl:ENSP00000390196}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]

128

14.1

MAP2K5-005

ENSP00000346493
ENST00000354498

Q13163
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Q13163 [Direct mapping]
Dual specificity mitogen-activated protein kinase kinase 5
H7BZL1 [Target identity:31%; Query identity:100%]
Dual-specificity mitogen-activated protein kinase kinase 5 {ECO:0000313|Ensembl:ENSP00000390196}

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000187 [activation of MAPK activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045415 [negative regulation of interleukin-8 biosynthetic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051247 [positive regulation of protein metabolic process]
GO:0060761 [negative regulation of response to cytokine stimulus]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071499 [cellular response to laminar fluid shear stress]
GO:0090051 [negative regulation of cell migration involved in sprouting angiogenesis]
GO:2000342 [negative regulation of chemokine (C-X-C motif) ligand 2 production]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]

412

46.1

MAP2K5-006

ENSP00000480580
ENST00000559262

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]

182

20.1

MAP2K5-009

ENSP00000483771
ENST00000557869

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

5.6

MAP2K5-013

ENSP00000378859
ENST00000395476

Q13163
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Q13163 [Direct mapping]
Dual specificity mitogen-activated protein kinase kinase 5
A0A024R5X5 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase kinase 5, isoform CRA_b {ECO:0000313|EMBL:EAW77802.1}
H7BZL1 [Target identity:29%; Query identity:100%]
Dual-specificity mitogen-activated protein kinase kinase 5 {ECO:0000313|Ensembl:ENSP00000390196}

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438

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.