BCL2L10

GENE INFORMATION

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Gene name

BCL2L10 (HGNC Symbol)

Synonyms

BCL-B, Boo, Diva

Description

BCL2-like 10 (apoptosis facilitator) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q21.2

Chromosome location (bp)

52109263 - 52112775

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137875 (version 78.38)

Entrez gene

10017

UniProt

Q9HD36 (UniProt - Evidence at protein level)

neXtProt

NX_Q9HD36

Antibodypedia

BCL2L10 antibodies
 

PROTEIN VIEW

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BCL2L10-001
 
BCL2L10-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BCL2L10-001 ENSP00000260442
ENST00000260442
Q9HD36
Show all »
Show » Show » 204 23.2 No 1
BCL2L10-002 ENSP00000453562
ENST00000561198
H0YMD5
Show all »
Show » Show » 241 26.7 No 0