FBXO11

GENE INFORMATION

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Gene name

FBXO11 (HGNC Symbol)

Synonyms

FBX11, UBR6

Description

F-box protein 11 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]

Chromosome

2

Cytoband

p16.3

Chromosome location (bp)

47789316 - 47905793

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000138081 (version 78.38)

Entrez gene

80204

UniProt

Q86XK2 (UniProt - Evidence at protein level)

neXtProt

NX_Q86XK2

Antibodypedia

FBXO11 antibodies
 

PROTEIN VIEW

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FBXO11-001
 
FBXO11-004
 
FBXO11-006
 
FBXO11-008
 
FBXO11-014
 
FBXO11-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FBXO11-001 ENSP00000384823
ENST00000403359
Q86XK2
Show all »
Show » Show » 927 103.6 No 0
FBXO11-004 ENSP00000392272
ENST00000424163
C9IYF0
Show all »
Show » Show » 140 16 No 0
FBXO11-006 ENSP00000428118
ENST00000493962
Show » 562 62.4 No 0
FBXO11-008 ENSP00000385398
ENST00000402508
Q86XK2
Show all »
Show » Show » 843 94.1 No 0
FBXO11-014 ENSP00000385127
ENST00000405808
B5MCV6
Show all »
Show » Show » 57 6.5 No 0
FBXO11-201 ENSP00000323822
ENST00000316377
Show » Show » 591 67 No 0