RBP4 - Gene info - The Human Protein Atlas

Gene name

RBP4

Synonyms

Description

Retinol binding protein 4, plasma (HGNC Symbol)

Entrez gene summary

This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

q23.33

Chromosome location (bp)

93591687 - 93601744

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000138207 (version 78.38)

Entrez gene

5950

UniProt

P02753 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RBP4-001

ENSP00000360519
ENST00000371464

P02753
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P02753 [Direct mapping]
Retinol-binding protein 4 Plasma retinol-binding protein(1-182) Plasma retinol-binding protein(1-181) Plasma retinol-binding protein(1-179) Plasma retinol-binding protein(1-176)

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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0001523 [retinoid metabolic process]
GO:0001654 [eye development]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0006094 [gluconeogenesis]
GO:0007507 [heart development]
GO:0007603 [phototransduction, visible light]
GO:0016918 [retinal binding]
GO:0019841 [retinol binding]
GO:0030277 [maintenance of gastrointestinal epithelium]
GO:0030324 [lung development]
GO:0032024 [positive regulation of insulin secretion]
GO:0032526 [response to retinoic acid]
GO:0034632 [retinol transporter activity]
GO:0034633 [retinol transport]
GO:0042572 [retinol metabolic process]
GO:0042593 [glucose homeostasis]
GO:0048562 [embryonic organ morphogenesis]
GO:0048706 [embryonic skeletal system development]
GO:0048738 [cardiac muscle tissue development]
GO:0048807 [female genitalia morphogenesis]
GO:0051024 [positive regulation of immunoglobulin secretion]
GO:0060044 [negative regulation of cardiac muscle cell proliferation]
GO:0060059 [embryonic retina morphogenesis in camera-type eye]
GO:0060065 [uterus development]
GO:0060068 [vagina development]
GO:0060157 [urinary bladder development]
GO:0060347 [heart trabecula formation]
GO:0070062 [extracellular vesicular exosome]

201

Yes

RBP4-002

ENSP00000360524
ENST00000371469

Q5VY30
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Q5VY30 [Target identity:100%; Query identity:100%]
Retinol binding protein 4, plasma, isoform CRA_b {ECO:0000313|EMBL:EAW50068.1}; Retinol-binding protein 4 {ECO:0000313|Ensembl:ENSP00000360524}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005215 [transporter activity]
GO:0005501 [retinoid binding]
GO:0005576 [extracellular region]
GO:0006810 [transport]
GO:0036094 [small molecule binding]

199

RBP4-003

ENSP00000360522
ENST00000371467

P02753
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GO:0001523 [retinoid metabolic process]
GO:0001654 [eye development]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0006094 [gluconeogenesis]
GO:0007283 [spermatogenesis]
GO:0007507 [heart development]
GO:0007603 [phototransduction, visible light]
GO:0008584 [male gonad development]
GO:0016918 [retinal binding]
GO:0019841 [retinol binding]
GO:0030277 [maintenance of gastrointestinal epithelium]
GO:0030324 [lung development]
GO:0032024 [positive regulation of insulin secretion]
GO:0032526 [response to retinoic acid]
GO:0032868 [response to insulin]
GO:0034632 [retinol transporter activity]
GO:0034633 [retinol transport]
GO:0042572 [retinol metabolic process]
GO:0042574 [retinal metabolic process]
GO:0042593 [glucose homeostasis]
GO:0043234 [protein complex]
GO:0045471 [response to ethanol]
GO:0046982 [protein heterodimerization activity]
GO:0048562 [embryonic organ morphogenesis]
GO:0048706 [embryonic skeletal system development]
GO:0048738 [cardiac muscle tissue development]
GO:0048807 [female genitalia morphogenesis]
GO:0050908 [detection of light stimulus involved in visual perception]
GO:0051024 [positive regulation of immunoglobulin secretion]
GO:0060041 [retina development in camera-type eye]
GO:0060044 [negative regulation of cardiac muscle cell proliferation]
GO:0060059 [embryonic retina morphogenesis in camera-type eye]
GO:0060065 [uterus development]
GO:0060068 [vagina development]
GO:0060157 [urinary bladder development]
GO:0060347 [heart trabecula formation]
GO:0070062 [extracellular vesicular exosome]

201

Yes

RBP4-201

ENSP00000480654
ENST00000615669

P02753
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199

22.9

Yes

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.