USP8

GENE INFORMATION

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Gene name

USP8 (HGNC Symbol)

Synonyms

HumORF8, KIAA0055, SPG59, UBPY

Description

Ubiquitin specific peptidase 8 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that belongs to the ubiquitin-specific processing protease family of proteins. The encoded protein is thought to regulate the morphology of the endosome by ubiquitination of proteins on this organelle and is involved in cargo sorting and membrane trafficking at the early endosome stage. This protein is required for the cell to enter the S phase of the cell cycle and also functions as a positive regulator in the Hedgehog signaling pathway in development. Pseudogenes of this gene are present on chromosomes 2 and 6. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Chromosome

15

Cytoband

q21.2

Chromosome location (bp)

50424380 - 50514419

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000138592 (version 78.38)

Entrez gene

9101

UniProt

P40818 (UniProt - Evidence at protein level)

neXtProt

NX_P40818

Antibodypedia

USP8 antibodies
 

PROTEIN VIEW

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USP8-001
 
USP8-002
 
USP8-003
 
USP8-008
 
USP8-011
 
USP8-017
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

USP8-001 ENSP00000379721
ENST00000396444
P40818
Show all »
Show » Show » 1118 127.5 No 0
USP8-002 ENSP00000412682
ENST00000425032
P40818
Show all »
Show » Show » 1012 115.1 No 0
USP8-003 ENSP00000302239
ENST00000307179
P40818
Show all »
Show » Show » 1118 127.5 No 0
USP8-008 ENSP00000453206
ENST00000560297
H0YLH2
Show all »
Show » 96 11.2 No 0
USP8-011 ENSP00000453427
ENST00000560982
H0YM17
Show all »
Show » 73 8.5 No 0
USP8-017 ENSP00000454059
ENST00000558091
H0YNL5
Show all »
Show » 135 15.9 No 0